Cited 3 times in
Increased 18F-FDG Uptake on PET/CT is Associated With Poor Arterial and Portal Perfusion on Multiphase CT
DC Field | Value | Language |
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dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이민욱 | - |
dc.contributor.author | 이나래 | - |
dc.contributor.author | 황상현 | - |
dc.date.accessioned | 2017-10-26T07:31:35Z | - |
dc.date.available | 2017-10-26T07:31:35Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0363-9762 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152144 | - |
dc.description.abstract | PURPOSE: To correlate 18F-FDG uptake on PET/CT with patterns of arterial and portal perfusion on multi-detector CT (MDCT) in patients with hepatocellular carcinoma (HCC) and to assess the value of variables from PET/CT and MDCT in predicting histological grades and overall survival. METHODS: We retrospectively analyzed MDCT and PET/CT of 66 patients with HCC who underwent surgical treatment. Tumor peak standard uptake value (SUV) was divided by the mean liver SUV (T/LSUV). The mean tumor Hounsfield unit (HU) to mean liver HU was calculated for arterial (T/LHU-A) and portal phases (T/LHU-P). All patients were divided into three groups: I, T/LHU-A ≤l and T/LHU-P <1; II, T/LHU-A >1 and T/LHU-P <1; and III, T/LHU-A >1 and T/LHU-P ≥1. The relationships between the CT perfusion groups and T/LSUV were assessed. Multivariate logistic regression analyses were performed using clinical and imaging parameters for predicting histological grade. Overall survival curves stratified by T/LSUV and CT perfusion groups were estimated using the Kaplan-Meier method. RESULTS: Statistically significant differences in T/LSUV were noted between groups I and II (2.29 [range 1.74-3.60] vs. 1.20 [range 1.07-1.58], P < 0.001) and groups I and III (2.29 [range 1.74-3.60] vs. 1.30 [range 1.07-1.43], P < 0.001). In multivariate analysis, a T/LSUV cutoff of >1.46 was the only independent predictor of tumor grade, with an odds ratio of 8.462 (95% confidence interval 1.799-39.803). Kaplan-Meier curves showed significant differences in OS according to T/LSUV >1.62, group I perfusion pattern, and T/LSUV >1.62 plus group I perfusion pattern (P = 0.04, P = 0.021, and P = 0.002, respectively). CONCLUSION: 18F-FDG PET/CT is not commonly used for detecting HCC due to its limited sensitivity. We found that increased 18F-FDG uptake is associated with decreased arterial and portal perfusion on MDCT. This can be used to preselect patients who would benefit the most from PET/CT. Meanwhile, 18F-FDG uptake remained as the only independent predictor of histological grade, and higher 18F-FDG uptake and lower perfusion pattern on MDCT were significantly related to shorter OS. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott | - |
dc.relation.isPartOf | CLINICAL NUCLEAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnostic imaging* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multimodal Imaging | - |
dc.subject.MESH | Perfusion Imaging* | - |
dc.subject.MESH | Portal System/diagnostic imaging* | - |
dc.subject.MESH | Positron-Emission Tomography* | - |
dc.subject.MESH | Radiopharmaceuticals* | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Increased 18F-FDG Uptake on PET/CT is Associated With Poor Arterial and Portal Perfusion on Multiphase CT | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Nuclear Medicine | - |
dc.contributor.googleauthor | Hwang, Sang Hyun | - |
dc.contributor.googleauthor | Lee, Minwook | - |
dc.contributor.googleauthor | Lee, Narae | - |
dc.contributor.googleauthor | Park, Saewhan | - |
dc.contributor.googleauthor | Kim, Chun Ki | - |
dc.contributor.googleauthor | Park, Mi-Ae | - |
dc.contributor.googleauthor | Yun, Mijin | - |
dc.identifier.doi | 10.1097/RLU.0000000000001105 | - |
dc.contributor.localId | A04998 | - |
dc.contributor.localId | A02703 | - |
dc.contributor.localId | A02550 | - |
dc.relation.journalcode | J00595 | - |
dc.identifier.eissn | 1536-0229 | - |
dc.identifier.pmid | 26756099 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003072-201604000-00007&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Minwook | - |
dc.contributor.alternativeName | Lee, Na Rae | - |
dc.contributor.affiliatedAuthor | Lee, Minwook | - |
dc.contributor.affiliatedAuthor | Lee, Na Rae | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 296 | - |
dc.citation.endPage | 301 | - |
dc.identifier.bibliographicCitation | CLINICAL NUCLEAR MEDICINE, Vol.41(4) : 296-301, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46923 | - |
dc.type.rims | ART | - |
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