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Upregulation of CD47 in Regulatory T Cells in Atopic Dermatitis

DC FieldValueLanguage
dc.contributor.author노지연-
dc.contributor.author박창욱-
dc.contributor.author신정우-
dc.contributor.author이광훈-
dc.contributor.author이나라-
dc.date.accessioned2017-10-26T07:30:09Z-
dc.date.available2017-10-26T07:30:09Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152114-
dc.description.abstractPURPOSE: Regulatory T (Treg) cells are key modulators in the immune system. Recent studies have shown that atopic dermatitis (AD) patients have higher numbers of Treg cells; however, little is known about the specific phenotype and function of Treg cells in AD. MATERIALS AND METHODS: To identify differentially expressed proteins in peripheral induced Treg cells in AD and naturally derived Treg cells in normal controls, CD4?CD25? Treg cells were isolated from thymus tissue of normal mice and the spleens of AD mice. Membrane proteins were extracted, and quantitative proteomics labeling with Tandem Mass Tags (TMT) was performed, followed by one-dimensional liquid chromatography/tandem mass spectrometry analysis. RESULTS: Using TMT labeling, we identified 510 proteins, including 63 membrane proteins and 16 plasma membrane proteins. CD47 was one of the upregulated proteins in Treg cells in AD spleens. Although CD47 was expressed in all CD4? and CD8? T cells, a significantly higher expression of CD47 was observed in the Treg cells of AD mice and AD patients than in those of normal mice and healthy controls. Furthermore, Treg cells from the spleen showed a significantly higher expression of CD47 than those from the thymus. CONCLUSION: We found that CD47 is highly expressed in the Treg cells of AD mice, particularly in the spleen. Based on our results, we propose that CD47(high) Treg cells are likely induced Treg cells and that upregulated CD47 in the Treg cells of AD patients may play a role in the increased population of Treg cells in AD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCD4 Antigens/analysis-
dc.subject.MESHCD47 Antigen/metabolism*-
dc.subject.MESHDermatitis, Atopic/immunology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSpleen/cytology-
dc.subject.MESHSpleen/immunology-
dc.subject.MESHT-Lymphocytes/drug effects-
dc.subject.MESHT-Lymphocytes/immunology*-
dc.subject.MESHT-Lymphocytes, Regulatory/cytology-
dc.subject.MESHT-Lymphocytes, Regulatory/immunology-
dc.subject.MESHT-Lymphocytes, Regulatory/metabolism*-
dc.subject.MESHUp-Regulation*-
dc.titleUpregulation of CD47 in Regulatory T Cells in Atopic Dermatitis-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorNara Lee-
dc.contributor.googleauthorJung U Shin-
dc.contributor.googleauthorShan Jin-
dc.contributor.googleauthorKi Na Yun-
dc.contributor.googleauthorJin Young Kim-
dc.contributor.googleauthorChang Ook Park-
dc.contributor.googleauthorSeo Hyeong Kim-
dc.contributor.googleauthorJi Yeon Noh-
dc.contributor.googleauthorKwang Hoon Lee-
dc.identifier.doi10.3349/ymj.2016.57.6.1435-
dc.contributor.localIdA01716-
dc.contributor.localIdA02149-
dc.contributor.localIdA02674-
dc.contributor.localIdA02702-
dc.contributor.localIdA01296-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid27593872-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordCD47-
dc.subject.keywordTandem Mass Tags (TMT)-
dc.subject.keywordregulatory T cells-
dc.contributor.alternativeNameNoh, Ji Yeon-
dc.contributor.alternativeNamePark, Chang Ook-
dc.contributor.alternativeNameShin, Jung U-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.alternativeNameLee, Na Ra-
dc.contributor.affiliatedAuthorPark, Chang Ook-
dc.contributor.affiliatedAuthorShin, Jung U-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.contributor.affiliatedAuthorLee, Na Ra-
dc.contributor.affiliatedAuthorNoh, Ji Yeon-
dc.citation.volume57-
dc.citation.number6-
dc.citation.startPage1435-
dc.citation.endPage1445-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.57(6) : 1435-1445, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46894-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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