Cited 25 times in
The Effect of TNF-α Blocker HL036337 and Its Best Concentration to Inhibit Dry Eye Inflammation
DC Field | Value | Language |
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dc.contributor.author | 이형근 | - |
dc.contributor.author | 최웅락 | - |
dc.contributor.author | 최웅락 | - |
dc.date.accessioned | 2017-10-26T07:29:33Z | - |
dc.date.available | 2017-10-26T07:29:33Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1011-8942 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152101 | - |
dc.description.abstract | Purpose: Dry eye syndrome is commonly thought of as an inflammatory disease, and we have previously presented data showing the effectiveness of topical TNF-α blocker agents for the treatment of this condition. The purpose of this study was to investigate the effectiveness of the TNF-α blocking agent HL036337 compared to cyclosporine A for the treatment of dry eye induced inflammation in order to establish whether HL036337 represents a more effective method for suppressing inflammation. The efficacy of HL036337 and cyclosporine A was determined using an experimental murine dry eye model. Methods: The TNF-α blocker HL036337 is a modified form of TNF receptor I. Using dry eye induced C57BL/6 mice (n = 45), corneal erosion was measured at day 4 and 7 after topical treatment with cyclosporine A or HL036337. To determine the effective treatment dose, 0.25, 0.5, 1, 2.5, and 5 mg/mL of HL036337 were topically administered twice per day to dry eye induced murine corneas for 1 week. Results: The optimal concentration of the TNF-α blocker HL036337 for treatment of dry eye induced corneal erosion was determined to be 1 mg/mL. Dry eye induced corneal erosion was improved after 1 week with topically applied cyclosporine A and HL036337 at 1 mg/mL. Conclusions: HL036337 administered topically at 1 mg/mL effectively improved corneal erosion induced by dry eye. This finding may also suggest that inhibition of TNF-α can improve dry eye syndrome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | KJO | - |
dc.relation.isPartOf | Korean Journal of Ophthalmology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cornea/diagnostic imaging | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Dry Eye Syndromes/diagnosis | - |
dc.subject.MESH | Dry Eye Syndromes/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Microscopy, Acoustic | - |
dc.subject.MESH | Ophthalmic Solutions/administration & dosage | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/antagonists & inhibitors* | - |
dc.title | The Effect of TNF-α Blocker HL036337 and Its Best Concentration to Inhibit Dry Eye Inflammation | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Wungrak Choi | - |
dc.contributor.googleauthor | Hyemi Noh | - |
dc.contributor.googleauthor | Areum Yeo | - |
dc.contributor.googleauthor | Hanmil Jang | - |
dc.contributor.googleauthor | Hyea Kyung Ahn | - |
dc.contributor.googleauthor | Yeon Jung Song | - |
dc.contributor.googleauthor | Hyung Keun Lee | - |
dc.identifier.doi | 10.3341/kjo.2016.30.4.302 | - |
dc.contributor.localId | A04123 | - |
dc.contributor.localId | A03303 | - |
dc.relation.journalcode | J02931 | - |
dc.identifier.pmid | 27478358 | - |
dc.subject.keyword | Corneal erosion | - |
dc.subject.keyword | Dry eye | - |
dc.subject.keyword | HL036337 | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Tumor necrosis factor-alpha | - |
dc.contributor.alternativeName | Lee, Hyung Keun | - |
dc.contributor.alternativeName | Choi, Wung Rak | - |
dc.contributor.affiliatedAuthor | Choi, Wung Rak | - |
dc.contributor.affiliatedAuthor | Lee, Hyung Keun | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 302 | - |
dc.citation.endPage | 308 | - |
dc.identifier.bibliographicCitation | Korean Journal of Ophthalmology, Vol.30(4) : 302-308, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46881 | - |
dc.type.rims | ART | - |
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