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Stratified analysis of 800 Asian patients after robot-assisted radical prostatectomy with a median 64 months of follow up

Authors
 Ali Abdel Raheem  ;  Dae Keun Kim  ;  Glen Denmer Santok  ;  Ibrahim Alabdulaali  ;  Byung Ha Chung  ;  Young Deuk Choi  ;  Koon Ho Rha 
Citation
 International Journal of Urology, Vol.23(9) : 765-774, 2016 
Journal Title
 International Journal of Urology 
ISSN
 0919-8172 
Issue Date
2016
Keywords
long-term ; oncological outcomes ; prostate cancer ; radical prostatectomy ; robotic surgery
Abstract
OBJECTIVE: To report the 5-year oncological outcomes of robot-assisted radical prostatectomy from the largest series ever reported from Asia. METHODS: A retrospective analysis of 800 Asian patients who were treated with robot-assisted radical prostatectomy from July 2005 to May 2010 in the Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea was carried out. The primary end-point was to evaluate the biochemical recurrence. The secondary end-point was to show the biochemical recurrence-free survival, metastasis-free survival and cancer-specific survival. RESULTS: A total of 197 (24.65%), 218 (27.3%), and 385 (48.1%) patients were classified as low-, intermediate- and high-risk patients according to the D'Amico risk stratification risk criteria, respectively. The median follow-up period was 64 months (interquartile range 28-71 months). The overall incidence of positive surgical margin was 36.6%. There was biochemical recurrence in 183 patients (22.9%), 38 patients (4.8%) developed distant metastasis and 24 patients (3%) died from prostate cancer. Actuarial biochemical recurrence-free survival, metastasis-free survival, and cancer-specific survival rates at 5 years were 76.4%, 94.6% and 96.7%, respectively. Positive lymph node was associated with lower 5-year biochemical recurrence-free survival (9.1%), cancer-specific survival (75.7%) and metastasis-free survival (61.9%) rates (P < 0.001). On multivariable analysis, among all the predictors, positive lymph node was the strongest predictor of biochemical recurrence, cancer-specific survival and metastasis-free survival (P < 0.001). CONCLUSIONS: Herein we report the largest robot-assisted radical prostatectomy series from Asia. Robot-assisted radical prostatectomy is confirmed to be an oncologically safe procedure that is able to provide effective 5-year cancer control, even in patients with high-risk disease.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/iju.13151/abstract
DOI
10.1111/iju.13151
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
Yonsei Authors
김대근(Kim, Dae Keun)
나군호(Rha, Koon Ho) ORCID logo https://orcid.org/0000-0001-8588-7584
알리압델(Raheem, Ali Abdel)
정병하(Chung, Byung Ha) ORCID logo https://orcid.org/0000-0001-9817-3660
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152070
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