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Changes in posterior corneal elevations after combined transepithelial photorefractive keratectomy and accelerated corneal collagen cross-linking: retrospective, comparative observational case series

Authors
 Hun Lee  ;  David Sung Yong Kang  ;  Byoung Jin Ha  ;  Jin Young Choi  ;  Eung Kweon Kim  ;  Kyoung Yul Seo  ;  Tae-im Kim 
Citation
 BMC OPHTHALMOLOGY, Vol.16 : 139, 2016 
Journal Title
 BMC OPHTHALMOLOGY 
Issue Date
2016
MeSH
Adult ; Collagen/metabolism ; Combined Modality Therapy ; Cornea/pathology* ; Corneal Stroma/metabolism ; Corneal Topography ; Cross-Linking Reagents/therapeutic use* ; Epithelium, Corneal/surgery ; Female ; Humans ; Male ; Myopia/surgery* ; Photochemotherapy ; Photorefractive Keratectomy*/adverse effects ; Photorefractive Keratectomy*/methods ; Photosensitizing Agents/therapeutic use ; Postoperative Complications* ; Retrospective Studies ; Tomography, X-Ray Computed ; Young Adult
Keywords
Accelerated corneal collagen cross-linking ; Best-fit toric ellipsoid ; Posterior corneal elevations ; Scheimpflug tomography ; Transepithelial photorefractive keratectomy
Abstract
Background : To compare the changes in anterior and posterior corneal elevations after combined transepithelial photorefractive keratectomy (PRK) and accelerated corneal collagen cross-linking (CXL) and after PRK. Methods : Medical records of 82 eyes of 44 patients undergoing either combined transepithelial PRK and CXL (PRK-CXL group) or transepithelial PRK (PRK group) were examined retrospectively. Changes in anterior and posterior corneal elevations were calculated by fitting an 8.0-mm diameter best-fit sphere and best-fit toric ellipsoid (BFTE) to the corneal shape with a fixed eccentricity of 0.4 using Scheimpflug tomography (Pentacam HR; Oculus Optikger?te GmbH, Wetzlar, Germany) preoperatively and 6 months postoperatively. Results : In anterior corneal elevation, both groups demonstrated a similar trend of a forward displacement of peripheral anterior corneal surface and a backward displacement of central anterior corneal surface. In posterior corneal elevation, a forward displacement of peripheral posterior corneal surface was induced in both groups, along with a backward displacement of central posterior corneal surface, regardless of the calculation method. The magnitudes of displacement of peripheral and central posterior corneal surfaces were significantly smaller in the PRK-CXL group than in the PRK group. Moreover, the PRK-CXL group showed a backward displacement of posterior corneal surface at maximum corneal elevations when the BFTE was used as the reference surface. Conclusions : Transepithelial PRK combined with prophylactic CXL significantly reduced the magnitudes of displacement of peripheral and central posterior corneal surfaces, with the radius of the BFTE was set to 8.0-mm on the Scheimpflug tomography system.
Files in This Item:
T201603628.pdf Download
DOI
10.1186/s12886-016-0320-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152038
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