Cited 8 times in
Total intraglandular and index tumor volumes predict biochemical recurrence in prostate cancer
DC Field | Value | Language |
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dc.contributor.author | 박성윤 | - |
dc.contributor.author | 이주용 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 신수진 | - |
dc.contributor.author | 박철근 | - |
dc.date.accessioned | 2017-10-26T07:26:13Z | - |
dc.date.available | 2017-10-26T07:26:13Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0945-6317 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152026 | - |
dc.description.abstract | Prognostic value of tumor volume for biochemical recurrence of prostate cancer remains controversial. We aimed to determine which tumor volume definition would optimally correlate with established prognostic factors and classify macroscopic tumor configuration. Radical prostatectomy specimens with follow-up to biochemical recurrence in the period between 2009 and 2012 were retrieved. Newly proposed categories of reconstructed three-dimensional macroscopic tumor configuration were nodular, medial prominence, subcapsular spreading, and miliary types. Several algorithms were applied to identify optimal tumor volume including (1) combined volume of all nodules, (2) volume of largest nodule as index tumor, and (3) volume of nodule with strongest evidence of poor prognosis. Macroscopic typing correlated well with radiologic findings, and nodular type was most common (70.7 %). In most multifocal tumors, the largest nodule showed the highest Gleason score (90.8 %) as well as extraprostatic extension or seminal vesicle invasion (93.5 %). Total tumor and index tumor volumes were significant predictors of biochemical recurrence (both, P < 0.0001). Tumor volume, classified in three groups with cutoff values at 2 and 5 cm(3), was independently predictive of recurrence-free survival in multivariate analysis (P < 0.05) and surpassed bilaterality even in stage pT2. In pT2 disease, recurrence-free survival was significantly associated with total tumor volume (P = 0.003) and index tumor volume (P = 0.002), but not with pT2 substage (P = 0.278). The proposed macroscopic classification system can be correlated with preoperative imaging findings. Total tumor or index tumor volume significantly predicts biochemical recurrence. Tumor volume classification is easy to apply in practice with high reproducibility and offsets the limitations of pT classification. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | VIRCHOWS ARCHIV | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prostate-Specific Antigen/metabolism* | - |
dc.subject.MESH | Prostatectomy/methods | - |
dc.subject.MESH | Prostatic Neoplasms/diagnosis* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology* | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Tumor Burden/physiology | - |
dc.title | Total intraglandular and index tumor volumes predict biochemical recurrence in prostate cancer | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Su-Jin Shin | - |
dc.contributor.googleauthor | Cheol Keun Park | - |
dc.contributor.googleauthor | Sung Yoon Park | - |
dc.contributor.googleauthor | Won Sik Jang | - |
dc.contributor.googleauthor | Joo Yong Lee | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.identifier.doi | 10.1007/s00428-016-1971-4 | - |
dc.contributor.localId | A03161 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04596 | - |
dc.contributor.localId | A01509 | - |
dc.contributor.localId | A05268 | - |
dc.relation.journalcode | J02784 | - |
dc.identifier.eissn | 1432-2307 | - |
dc.identifier.pmid | 27306657 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00428-016-1971-4 | - |
dc.subject.keyword | Neoplasm grading | - |
dc.subject.keyword | Prostatic neoplasms | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Tumor burden | - |
dc.contributor.alternativeName | Park, Sung Yoon | - |
dc.contributor.alternativeName | Lee, Joo Yong | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Shin, Su Jin | - |
dc.contributor.affiliatedAuthor | Lee, Joo Yong | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Shin, Su Jin | - |
dc.contributor.affiliatedAuthor | Park, Sung Yoon | - |
dc.citation.volume | 469 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 312 | - |
dc.identifier.bibliographicCitation | VIRCHOWS ARCHIV, Vol.469(3) : 305-312, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46348 | - |
dc.type.rims | ART | - |
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