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Clinical Practice Guidelines for the Management of Atypical Hemolytic Uremic Syndrome in Korea

Authors
 Hae Il Cheong  ;  Sang Kyung Jo  ;  Sung-Soo Yoon  ;  Heeyeon Cho  ;  Jin Seok Kim  ;  Young Ok Kim  ;  Ja-Ryong Koo  ;  Yong Park  ;  Young Seo Park  ;  Jae Il Shin  ;  Kee Hwan Yoo  ;  Doyeun Oh 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.31(10) : 1516-1528, 2016 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2016
MeSH
ADAMTS13 Protein/genetics ; ADAMTS13 Protein/metabolism ; Acute Kidney Injury/etiology ; Antibodies, Monoclonal, Humanized/therapeutic use* ; Atypical Hemolytic Uremic Syndrome/diagnosis* ; Atypical Hemolytic Uremic Syndrome/epidemiology ; Atypical Hemolytic Uremic Syndrome/therapy ; Blood Transfusion* ; Complement Factor H/genetics ; Complement System Proteins/genetics ; Complement System Proteins/metabolism ; Delayed Diagnosis ; Humans ; Kidney Failure, Chronic/etiology ; Organ Transplantation* ; Republic of Korea/epidemiology
Keywords
Atypical Hemolytic Uremic Syndrome ; Diagnosis ; Guidelines ; Treatment
Abstract
Atypical hemolytic uremic syndrome (aHUS) is a rare syndrome characterized by micro-angiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The major pathogenesis of aHUS involves dysregulation of the complement system. Eculizumab, which blocks complement C5 activation, has recently been proven as an effective agent. Delayed diagnosis and treatment of aHUS can cause death or end-stage renal disease. Therefore, a diagnosis that differentiates aHUS from other forms of thrombotic microangiopathy is very important for appropriate management. These guidelines aim to offer recommendations for the diagnosis and treatment of patients with aHUS in Korea. The guidelines have largely been adopted from the current guidelines due to the lack of evidence concerning the Korean population.
Files in This Item:
T201603515.pdf Download
DOI
10.3346/jkms.2016.31.10.1516
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152018
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