0 456

Cited 20 times in

Role of mitochondrial function in cell death and body metabolism

Authors
 Myung-Shik Lee 
Citation
 FRONTIERS IN BIOSCIENCE-LANDMARK, Vol.21 : 1233-1244, 2016 
Journal Title
FRONTIERS IN BIOSCIENCE-LANDMARK
Issue Date
2016
MeSH
Animals ; Apoptosis/physiology ; Autophagy/physiology ; Cell Death/physiology* ; DNA, Mitochondrial/metabolism ; Humans ; Longevity/physiology ; Mitochondria/physiology* ; Necrosis ; Stress, Physiological ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Keywords
Mitochondria ; Apoptosis ; Cell Death ; ROS ; Aging ; Autophagy ; Mitokine ; Senescence ; Review
Abstract
Mitochondria are the key players in apoptosis and necrosis. Mitochondrial DNA (mtDNA)-depleted r0 cells were resistant to diverse apoptosis inducers such as TNF-alpha, TNFSF10, staurosporine and p53. Apoptosis resistance was accompanied by the absence of mitochondrial potential loss or cytochrome c translocation. r0 cells were also resistant to necrosis induced by reactive oxygen species (ROS) donors due to upregulation of antioxidant enzymes such as manganese superoxide dismutase. Mitochondria also has a close relationship with autophagy that plays a critical role in the turnover of senescent organelles or dysfunctional proteins and may be included in 'cell death' category. It was demonstrated that autophagy deficiency in insulin target tissues such as skeletal muscle induces mitochondrial stress response, which leads to the induction of FGF21 as a 'mitokine' and affects the whole body metabolism. These results show that mitochondria are not simply the power plants of cells generating ATP, but are closely related to several types of cell death and autophagy. Mitochondria affect various pathophysiological events related to diverse disorders such as cancer, metabolic disorders and aging.
Full Text
https://www.bioscience.org/2016/v21/af/4453/list.htm
DOI
10.2741/4453
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Lee, Myung Shik(이명식) ORCID logo https://orcid.org/0000-0003-3292-1720
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151987
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links