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Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis

Authors
 Seung-Chul Lee  ;  Jung Min Bae  ;  Ho-June Lee  ;  Hyun Jung Kim  ;  Byung-Soo Kim  ;  Kapsok Li  ;  Jae-We Cho  ;  Chang Ook Park  ;  Sang Hyun Cho  ;  Kwang Hoon Lee  ;  Do-Won Kim  ;  Chun Wook Park  ;  Kyu Han Kim 
Citation
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.8(3) : 230-238, 2016 
Journal Title
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 
ISSN
 2092-7355 
Issue Date
2016
Keywords
Atopic dermatitis ; REACH ; diagnostic criteria ; questionnnaire
Abstract
PURPOSE: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. METHODS: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=1,129) and validation (n=1,191) sets by community-based surveys. RESULTS: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3% (95% CI, 10.5%-14.2%), and the REACH showed a sensitivity of 75.2%, a specificity of 96.1%, and an error rate of 6.4%. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0%). CONCLUSIONS: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys.
Files in This Item:
T201603370.pdf Download
DOI
10.4168/aair.2016.8.3.230
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
Lee, Kwang Hoon(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151953
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