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Time-dependent effects of ultraviolet and nonthermal atmospheric pressure plasma on the biological activity of titanium

 Sung-Hwan Choi  ;  Won-Seok Jeong  ;  Jung-Yul Cha  ;  Jae-Hoon Lee  ;  Hyung-Seog Yu  ;  Eun-Ha Choi  ;  Kwang-Mahn Kim  ;  Chung-Ju Hwang 
 SCIENTIFIC REPORTS, Vol.6 : 33421, 2016 
Journal Title
Issue Date
Adsorption ; Albumins/chemistry ; Alkaline Phosphatase/metabolism ; Animals ; Cell Adhesion/drug effects ; Cell Line ; Cell Shape/drug effects ; Hydrophobic and Hydrophilic Interactions ; Imaging, Three-Dimensional ; Mice ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Plasma Gases/pharmacology* ; Surface Properties ; Time Factors ; Titanium/pharmacology* ; Ultraviolet Rays*
Here, we evaluated time-dependent changes in the effects of ultraviolet (UV) and nonthermal atmospheric pressure plasma (NTAPPJ) on the biological activity of titanium compared with that of untreated titanium. Grade IV machined surface titanium discs (12-mm diameter) were used immediately and stored up to 28 days after 15-min UV or 10-min NTAPPJ treatment. Changes of surface characteristics over time were evaluated using scanning electron microscopy, surface profiling, contact angle analysis, X-ray photoelectron spectroscopy, and surface zeta-potential. Changes in biological activity over time were as determined by analysing bovine serum albumin adsorption, MC3T3-E1 early adhesion and morphometry, and alkaline phosphatase (ALP) activity between groups. We found no differences in the effects of treatment on titanium between UV or NTAPPJ over time; both treatments resulted in changes from negatively charged hydrophobic (bioinert) to positively charged hydrophilic (bioactive) surfaces, allowing enhancement of albumin adsorption, osteoblastic cell attachment, and cytoskeleton development. Although this effect may not be prolonged for promotion of cell adhesion until 4 weeks, the effects were sufficient to maintain ALP activity after 7 days of incubation. This positive effect of UV and NTAPPJ treatment can enhance the biological activity of titanium over time.
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Yu, Hyung Seog(유형석) ORCID logo https://orcid.org/0000-0002-1275-5078
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0003-2281-8885
Cha, Jung Yul(차정열)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
Hwang, Chung Ju(황충주) ORCID logo https://orcid.org/0000-0003-3024-4551
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