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Baseline polyp size as a potential predictive factor for recurrence of polypoidal choroidal vasculopathy

Authors
 Hae Min Kang  ;  Hyoung Jun Koh  ;  Sung Chul Lee 
Citation
 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.254(8) : 1519-1527, 2016 
Journal Title
 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 
ISSN
 0721-832X 
Issue Date
2016
MeSH
Aged ; Angiogenesis Inhibitors/administration & dosage ; Choroid/diagnostic imaging* ; Choroid Diseases/diagnosis ; Choroid Diseases/drug therapy* ; Female ; Fluorescein Angiography ; Humans ; Male ; Photochemotherapy/methods* ; Polyps/diagnosis ; Polyps/drug therapy* ; Prognosis ; Ranibizumab/administration & dosage* ; Recurrence ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity
Keywords
Anti-vascular endothelial growth factor therapy ; Photodynamic therapy ; Polypoidal choroidal vasculopathy ; Recurrence
Abstract
PURPOSE: To investigate the predictive factors for recurrence of polypoidal choroidal vasculopathy (PCV). METHODS: The medical records of 78 consecutive patients (78 eyes) with treatment-na?ve PCV who responded to first-line treatment and completed at least a 3-year follow-up after the first remission were retrospectively analyzed. In this comparative cohort study, baseline characteristics were compared between the patients who had at least one recurrence (the recurrence group) and those without recurrence (the non-recurrence group) during at least 3-year follow-up periods. In addition, possible predictive factors for recurrence of PCV were investigated by using Cox regression analysis. RESULTS: Within 3 years of the first remission, 50 eyes (64 %) showed at least one recurrence (mean 1.5; 1 to ∼2 times). There were no significant differences in the baseline characteristics between the recurrence group and the non-recurrence group. However, the largest polyp diameter was significantly different: the mean largest polyp diameter (524?±?340 μm) was significantly larger in the recurrence group compared to that of the non-recurrence group (352?±?173 μm; P?=?0.038). Cox regression analysis showed that the largest polyp diameter at baseline significantly correlated with recurrence of PCV (B?=?1.470, P?=?0.015). CONCLUSIONS: The largest polyp diameter at baseline may be predictive for PCV recurrence, as it was significantly larger in patients who had at least one recurrence.
Full Text
https://link.springer.com/article/10.1007%2Fs00417-015-3241-6
DOI
10.1007/s00417-015-3241-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151914
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