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High-risk clinicopathological features and their predictive significance in Korean patients with stage II colon cancer

Authors
 Ji Soo Park  ;  Hong Jae Chon  ;  Hei-Cheul Jeung  ;  Sang Joon Shin  ;  Sun Young Rha  ;  Joong Bae Ahn  ;  Kang Young Lee  ;  Nam Kyu Kim  ;  Hyun Cheol Chung 
Citation
 Journal of Cancer Research and Clinical Oncology, Vol.142(9) : 2051-2059, 2016 
Journal Title
 Journal of Cancer Research and Clinical Oncology 
ISSN
 0171-5216 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/physiology* ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/mortality* ; Colonic Neoplasms/pathology* ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; Republic of Korea/epidemiology ; Risk Factors ; Survival Analysis
Keywords
Colon cancer ; Predictive factor ; Prognostic factor ; Stage II
Abstract
PURPOSE: We investigated the prognostic factors for recurrence in Korean patients with stage II colon cancer and evaluated their predictive significance with 5-fluorouracil (FU)-based adjuvant chemotherapy. METHODS: We analyzed the relationship between clinicopathological features and relapse-free survival (RFS) of 716 stage II colon cancer patients who underwent curative resection. Predictive values were assessed using 5-year RFS and 5-year cancer-specific survival (CSS). RESULTS: The 5-year RFS, 5-year CSS, 5-year disease-free survival, and 5-year overall survival rates were 87.4, 94.9, 84.8, and 90.5 %, respectively. T4 stage (hazard ratio [HR], 2.342; 95 % confidence interval [CI], 1.348-4.068; p = 0.003), preoperative bowel obstruction or perforation (HR 2.428; 95 % CI 1.241-4.752; p = 0.010), and age older than 70 years (HR 1.740; 95 % CI 1.130-2.678; p = 0.012) were poor prognostic factors for recurrence in multiple Cox regression analyses. In 60 patients with T4 disease, 5-FU-based adjuvant chemotherapy was associated with improved 5-year CSS of the patients (90.3 vs. 46.7 %; HR 0.135; 95 % CI 0.035-0.517; p = 0.003). CONCLUSIONS: We found discordance between the risk factors for recurrence and the predictive value for 5-FU-based adjuvant chemotherapy in Korean patients with stage II colon cancer. Future prospective clinical trials selectively targeting high-risk patients are needed.
Full Text
https://link.springer.com/article/10.1007%2Fs00432-016-2208-2
DOI
10.1007/s00432-016-2208-2
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
박지수(Park, Ji Soo) ORCID logo https://orcid.org/0000-0002-0023-7740
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
이강영(Lee, Kang Young)
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
정희철(Jeung, Hei Cheul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151908
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