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Atrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease

 Pil-Sung Yang  ;  Seung Hyun Lee  ;  Junbeom Park  ;  Tae-Hoon Kim  ;  Jae-Sun Uhm  ;  Boyoung Joung  ;  Moon-Hyoung Lee  ;  Byung-Chul Chang  ;  Hui-Nam Pak 
 International Journal of Cardiology, Vol.220 : 1-6, 2016 
Journal Title
 International Journal of Cardiology 
Issue Date
Adult ; Aged ; Antigens, Neoplasm/biosynthesis* ; Antigens, Neoplasm/genetics ; Female ; Fibrosis/diagnostic imaging ; Fibrosis/metabolism ; Gene Expression ; Heart Atria/metabolism* ; Heart Atria/pathology* ; Humans ; Male ; Middle Aged ; Mitogen-Activated Protein Kinases/biosynthesis* ; Mitogen-Activated Protein Kinases/genetics ; Mitral Valve Insufficiency/genetics ; Mitral Valve Insufficiency/metabolism* ; Mitral Valve Insufficiency/pathology*
Atrial fibrillation ; Atrial fibrosis ; Mitral valve disease ; RAGE
BACKGROUND: It has been reported that receptor for advanced glycation end-products (RAGE) plays a significant role in cardiac fibrosis. Nonetheless, the precise relationship between the RAGE and atrial fibrosis has never been studied in humans. The aim of this study was to determine whether degree of atrial fibrosis was associated with atrial tissue expression of RAGE in patients with mitral valve disease (MVD). METHODS: We collected human left atrial (LA) appendage tissue from 25 patients who underwent mitral valve surgery. We quantified the expression of RAGE and other protein markers by Western blotting and compared these levels with histological evaluations. RESULTS: RAGE expression in the LA appendage tissue was significantly correlated with atrial fibrosis (r=0.681, p=0.001). RAGE expression (regression coefficient [B] 9.49, 95% confidence interval [CI] 4.76-14.2, p<0.001) and LA diameter (B 0.43, 95% CI 0.13-0.74, p=0.008) were independently associated with degree of atrial fibrosis in multiple linear regression analysis. RAGE expression was significantly correlated with protein expression of von Willebrand factor (r=0.659, p<0.001), vascular endothelial cadherin (r=0.757, p<0.001), ICAM-1 (r=0.568, p=0.003), and PECAM-1 (r=0.423, p=0.035) in the LA appendage tissue. In addition, patients with severe mitral stenosis (MS) had higher atrial RAGE expression than those with no, mild, or moderate MS (p=0.013). Patients with MVD and atrial fibrillation (AF) had more severe atrial fibrosis (p=0.024) and higher RAGE expression (p=0.047) than those who remained in sinus rhythm. CONCLUSIONS: Atrial tissue expression of RAGE was significantly associated with atrial fibrosis, severe MS, and AF rhythm in patients with MVD.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
김태훈(Kim, Tae-Hoon) ORCID logo https://orcid.org/0000-0003-4200-3456
박희남(Pak, Hui Nam) ORCID logo https://orcid.org/0000-0002-3256-3620
양필성(Yang, Pil Sung)
엄재선(Uhm, Jae Sun) ORCID logo https://orcid.org/0000-0002-1611-8172
이문형(Lee, Moon Hyoung) ORCID logo https://orcid.org/0000-0002-7268-0741
이승현(Lee, Seung Hyun) ORCID logo https://orcid.org/0000-0002-0311-6565
장병철(Chang, Byung Chul)
정보영(Joung, Bo Young) ORCID logo https://orcid.org/0000-0001-9036-7225
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