0 583

Cited 6 times in

Atrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease

DC Field Value Language
dc.contributor.author김태훈-
dc.contributor.author양필성-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.contributor.author이문형-
dc.contributor.author이승현-
dc.contributor.author장병철-
dc.contributor.author정보영-
dc.date.accessioned2017-10-26T07:20:26Z-
dc.date.available2017-10-26T07:20:26Z-
dc.date.issued2016-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151900-
dc.description.abstractBACKGROUND: It has been reported that receptor for advanced glycation end-products (RAGE) plays a significant role in cardiac fibrosis. Nonetheless, the precise relationship between the RAGE and atrial fibrosis has never been studied in humans. The aim of this study was to determine whether degree of atrial fibrosis was associated with atrial tissue expression of RAGE in patients with mitral valve disease (MVD). METHODS: We collected human left atrial (LA) appendage tissue from 25 patients who underwent mitral valve surgery. We quantified the expression of RAGE and other protein markers by Western blotting and compared these levels with histological evaluations. RESULTS: RAGE expression in the LA appendage tissue was significantly correlated with atrial fibrosis (r=0.681, p=0.001). RAGE expression (regression coefficient [B] 9.49, 95% confidence interval [CI] 4.76-14.2, p<0.001) and LA diameter (B 0.43, 95% CI 0.13-0.74, p=0.008) were independently associated with degree of atrial fibrosis in multiple linear regression analysis. RAGE expression was significantly correlated with protein expression of von Willebrand factor (r=0.659, p<0.001), vascular endothelial cadherin (r=0.757, p<0.001), ICAM-1 (r=0.568, p=0.003), and PECAM-1 (r=0.423, p=0.035) in the LA appendage tissue. In addition, patients with severe mitral stenosis (MS) had higher atrial RAGE expression than those with no, mild, or moderate MS (p=0.013). Patients with MVD and atrial fibrillation (AF) had more severe atrial fibrosis (p=0.024) and higher RAGE expression (p=0.047) than those who remained in sinus rhythm. CONCLUSIONS: Atrial tissue expression of RAGE was significantly associated with atrial fibrosis, severe MS, and AF rhythm in patients with MVD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, Neoplasm/biosynthesis*-
dc.subject.MESHAntigens, Neoplasm/genetics-
dc.subject.MESHFemale-
dc.subject.MESHFibrosis/diagnostic imaging-
dc.subject.MESHFibrosis/metabolism-
dc.subject.MESHGene Expression-
dc.subject.MESHHeart Atria/metabolism*-
dc.subject.MESHHeart Atria/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMitogen-Activated Protein Kinases/biosynthesis*-
dc.subject.MESHMitogen-Activated Protein Kinases/genetics-
dc.subject.MESHMitral Valve Insufficiency/genetics-
dc.subject.MESHMitral Valve Insufficiency/metabolism*-
dc.subject.MESHMitral Valve Insufficiency/pathology*-
dc.titleAtrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorPil-Sung Yang-
dc.contributor.googleauthorSeung Hyun Lee-
dc.contributor.googleauthorJunbeom Park-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorByung-Chul Chang-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1016/j.ijcard.2016.06.137-
dc.contributor.localIdA02323-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA02766-
dc.contributor.localIdA02935-
dc.contributor.localIdA03430-
dc.contributor.localIdA03609-
dc.contributor.localIdA01085-
dc.relation.journalcodeJ01093-
dc.identifier.eissn1874-1754-
dc.identifier.pmid27372036-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167527316311391-
dc.subject.keywordAtrial fibrillation-
dc.subject.keywordAtrial fibrosis-
dc.subject.keywordMitral valve disease-
dc.subject.keywordRAGE-
dc.contributor.alternativeNameKim, Tae Hoon-
dc.contributor.alternativeNameYang, Pil Sung-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameLee, Seung Hyun-
dc.contributor.alternativeNameChang, Byung Chul-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.affiliatedAuthorYang, Pil Sung-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorLee, Seung Hyun-
dc.contributor.affiliatedAuthorChang, Byung Chul-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.contributor.affiliatedAuthorKim, Tae-Hoon-
dc.citation.volume220-
dc.citation.startPage1-
dc.citation.endPage6-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.220 : 1-6, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46225-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.