Cited 6 times in
Atrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease
DC Field | Value | Language |
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dc.contributor.author | 김태훈 | - |
dc.contributor.author | 양필성 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 장병철 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2017-10-26T07:20:26Z | - |
dc.date.available | 2017-10-26T07:20:26Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151900 | - |
dc.description.abstract | BACKGROUND: It has been reported that receptor for advanced glycation end-products (RAGE) plays a significant role in cardiac fibrosis. Nonetheless, the precise relationship between the RAGE and atrial fibrosis has never been studied in humans. The aim of this study was to determine whether degree of atrial fibrosis was associated with atrial tissue expression of RAGE in patients with mitral valve disease (MVD). METHODS: We collected human left atrial (LA) appendage tissue from 25 patients who underwent mitral valve surgery. We quantified the expression of RAGE and other protein markers by Western blotting and compared these levels with histological evaluations. RESULTS: RAGE expression in the LA appendage tissue was significantly correlated with atrial fibrosis (r=0.681, p=0.001). RAGE expression (regression coefficient [B] 9.49, 95% confidence interval [CI] 4.76-14.2, p<0.001) and LA diameter (B 0.43, 95% CI 0.13-0.74, p=0.008) were independently associated with degree of atrial fibrosis in multiple linear regression analysis. RAGE expression was significantly correlated with protein expression of von Willebrand factor (r=0.659, p<0.001), vascular endothelial cadherin (r=0.757, p<0.001), ICAM-1 (r=0.568, p=0.003), and PECAM-1 (r=0.423, p=0.035) in the LA appendage tissue. In addition, patients with severe mitral stenosis (MS) had higher atrial RAGE expression than those with no, mild, or moderate MS (p=0.013). Patients with MVD and atrial fibrillation (AF) had more severe atrial fibrosis (p=0.024) and higher RAGE expression (p=0.047) than those who remained in sinus rhythm. CONCLUSIONS: Atrial tissue expression of RAGE was significantly associated with atrial fibrosis, severe MS, and AF rhythm in patients with MVD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, Neoplasm/biosynthesis* | - |
dc.subject.MESH | Antigens, Neoplasm/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrosis/diagnostic imaging | - |
dc.subject.MESH | Fibrosis/metabolism | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Heart Atria/metabolism* | - |
dc.subject.MESH | Heart Atria/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/biosynthesis* | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/genetics | - |
dc.subject.MESH | Mitral Valve Insufficiency/genetics | - |
dc.subject.MESH | Mitral Valve Insufficiency/metabolism* | - |
dc.subject.MESH | Mitral Valve Insufficiency/pathology* | - |
dc.title | Atrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Pil-Sung Yang | - |
dc.contributor.googleauthor | Seung Hyun Lee | - |
dc.contributor.googleauthor | Junbeom Park | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Byung-Chul Chang | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.1016/j.ijcard.2016.06.137 | - |
dc.contributor.localId | A02323 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A02935 | - |
dc.contributor.localId | A03430 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A01085 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 27372036 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167527316311391 | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | Atrial fibrosis | - |
dc.subject.keyword | Mitral valve disease | - |
dc.subject.keyword | RAGE | - |
dc.contributor.alternativeName | Kim, Tae Hoon | - |
dc.contributor.alternativeName | Yang, Pil Sung | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Uhm, Jae Sun | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Lee, Seung Hyun | - |
dc.contributor.alternativeName | Chang, Byung Chul | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Yang, Pil Sung | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Uhm, Jae Sun | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Chang, Byung Chul | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hoon | - |
dc.citation.volume | 220 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 6 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.220 : 1-6, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46225 | - |
dc.type.rims | ART | - |
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