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Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia

 Yong Duk Jeon  ;  Woo Yong Jeong  ;  Moo Hyun Kim  ;  In Young Jung  ;  Mi Young Ahn  ;  Hea Won Ann  ;  Jin Young Ahn  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Young Goo Song  ;  June Myung Kim  ;  Nam Su Ku 
 Medicine, Vol.95(31) : 4375-4375, 2016 
Journal Title
Issue Date
Adult ; Age Factors ; Aged ; Catheterization, Central Venous/adverse effects* ; Cause of Death ; Cohort Studies ; Cross Infection/etiology ; Cross Infection/mortality ; Databases, Factual ; Female ; Gram-Negative Bacterial Infections/etiology ; Gram-Negative Bacterial Infections/mortality* ; Gram-Negative Bacterial Infections/physiopathology ; Hospital Mortality* ; Humans ; Kaplan-Meier Estimate ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Retrospective Studies ; Risk Assessment ; Sex Factors ; Stenotrophomonas maltophilia/immunology* ; Survival Analysis ; Urinary Catheterization/adverse effects*
bacteremia ; central venous catheter ; mortality ; risk factor ; Stenotrophomonas maltophilia
Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia.Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality.In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P?=?0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P?<?0.001) and the removal of a central venous catheter (CVC) (P?=?0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P?=?0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR]?=?1.323; 95% confidence interval [CI]: 1.159, 1.509; P?<?0.001) and removal of the CVC (OR?=?0.330; 95% CI: 0.109, 0.996; P?=?0.049) were independent factors associated with mortality.Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.
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Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김무현(Kim, Moo Hyun)
김준명(Kim, June Myung)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
전용덕(Jeon, Yong Duk)
정우용(Jeong, Wooyong)
정인영(Jung, In Young)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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