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Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease

Authors
 Su Jin Chung  ;  Jae Jung Lee  ;  Jee Hyun Ham  ;  Byoung Seok Ye  ;  Phil Hyu Lee  ;  Young H. Sohn 
Citation
 PLOS ONE, Vol.11(8) : e0161316, 2016 
Journal Title
 PLOS ONE 
Issue Date
2016
MeSH
Aged ; Disease Progression ; Dopamine/deficiency* ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Female ; Humans ; Male ; Motor Activity ; Neostriatum/metabolism* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism* ; Parkinson Disease/physiopathology ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography
Abstract
BACKGROUND: The mechanism underlying non-motor symptoms in Parkinson's disease has not yet been elucidated. In this study, we hypothesized that Parkinson patients with more non-motor symptoms have a different pattern of striatal dopamine depletion, particularly in areas other than the sensorimotor striatum, compared to those with fewer non-motor symptoms. METHODS: We conducted a prospective survey of the degree of non-motor symptoms (using the Korean version of the Non-Motor Symptoms Scale; K-NMSS) in 151 patients with early-stage Parkinson's disease who had undergone a dopamine transporter PET scan as an initial diagnostic procedure. We classified the patients into two groups; high non-motor patients (HNM-PD; K-NMSS score ≥ 41) and low non-motor patients (LNM-PD). RESULTS: Patients in the HNM-PD group (n = 71) were older, had longer symptom duration, exhibited more severe motor deficits, and had been prescribed higher levodopa-equivalent doses at follow-up than those in the LNM-PD group. However, dopamine transporter binding to the striatal sub-regions and inter-sub-regional binding ratios were comparable between the two groups. A general linear model showed that the HNM-PD group had significantly more severe motor deficits than the LNM-PD group after controlling for age, gender, symptom duration, and dopamine transporter binding to the sensorimotor striatum. CONCLUSIONS: This study demonstrated that the pattern of striatal dopamine depletion does not contribute to early non-motor burden in Parkinson's disease. Our results suggest that LNM-PD patients may have a more benign course of motor symptom progression than HNM-PD patients.
Files in This Item:
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DOI
10.1371/journal.pone.0161316
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Su Jin(정수진)
Ham, Jee Hyun(함지현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151857
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