Cited 12 times in
Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 예병석 | - |
dc.contributor.author | 이재정 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 함지현 | - |
dc.date.accessioned | 2017-10-26T07:18:15Z | - |
dc.date.available | 2017-10-26T07:18:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151857 | - |
dc.description.abstract | BACKGROUND: The mechanism underlying non-motor symptoms in Parkinson's disease has not yet been elucidated. In this study, we hypothesized that Parkinson patients with more non-motor symptoms have a different pattern of striatal dopamine depletion, particularly in areas other than the sensorimotor striatum, compared to those with fewer non-motor symptoms. METHODS: We conducted a prospective survey of the degree of non-motor symptoms (using the Korean version of the Non-Motor Symptoms Scale; K-NMSS) in 151 patients with early-stage Parkinson's disease who had undergone a dopamine transporter PET scan as an initial diagnostic procedure. We classified the patients into two groups; high non-motor patients (HNM-PD; K-NMSS score ≥ 41) and low non-motor patients (LNM-PD). RESULTS: Patients in the HNM-PD group (n = 71) were older, had longer symptom duration, exhibited more severe motor deficits, and had been prescribed higher levodopa-equivalent doses at follow-up than those in the LNM-PD group. However, dopamine transporter binding to the striatal sub-regions and inter-sub-regional binding ratios were comparable between the two groups. A general linear model showed that the HNM-PD group had significantly more severe motor deficits than the LNM-PD group after controlling for age, gender, symptom duration, and dopamine transporter binding to the sensorimotor striatum. CONCLUSIONS: This study demonstrated that the pattern of striatal dopamine depletion does not contribute to early non-motor burden in Parkinson's disease. Our results suggest that LNM-PD patients may have a more benign course of motor symptom progression than HNM-PD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Dopamine/deficiency* | - |
dc.subject.MESH | Dopamine Plasma Membrane Transport Proteins/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Motor Activity | - |
dc.subject.MESH | Neostriatum/metabolism* | - |
dc.subject.MESH | Parkinson Disease/diagnostic imaging | - |
dc.subject.MESH | Parkinson Disease/metabolism* | - |
dc.subject.MESH | Parkinson Disease/physiopathology | - |
dc.subject.MESH | Positron Emission Tomography Computed Tomography | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.title | Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Su Jin Chung | - |
dc.contributor.googleauthor | Jae Jung Lee | - |
dc.contributor.googleauthor | Jee Hyun Ham | - |
dc.contributor.googleauthor | Byoung Seok Ye | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Young H. Sohn | - |
dc.identifier.doi | 10.1371/journal.pone.0161316 | - |
dc.contributor.localId | A04603 | - |
dc.contributor.localId | A03082 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04668 | - |
dc.contributor.localId | A04338 | - |
dc.contributor.localId | A01982 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 27529171 | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.alternativeName | Ye, Byoung Seok | - |
dc.contributor.alternativeName | Lee, Jae Jung | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.alternativeName | Chung, Su Jin | - |
dc.contributor.alternativeName | Ham, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Ye, Byoung Seok | - |
dc.contributor.affiliatedAuthor | Lee, Jae Jung | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Chung, Su Jin | - |
dc.contributor.affiliatedAuthor | Ham, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Sohn, Young Ho | - |
dc.citation.volume | 11 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | e0161316 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(8) : e0161316, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46182 | - |
dc.type.rims | ART | - |
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