240 530

Cited 12 times in

Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author이재정-
dc.contributor.author이필휴-
dc.contributor.author정수진-
dc.contributor.author함지현-
dc.date.accessioned2017-10-26T07:18:15Z-
dc.date.available2017-10-26T07:18:15Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151857-
dc.description.abstractBACKGROUND: The mechanism underlying non-motor symptoms in Parkinson's disease has not yet been elucidated. In this study, we hypothesized that Parkinson patients with more non-motor symptoms have a different pattern of striatal dopamine depletion, particularly in areas other than the sensorimotor striatum, compared to those with fewer non-motor symptoms. METHODS: We conducted a prospective survey of the degree of non-motor symptoms (using the Korean version of the Non-Motor Symptoms Scale; K-NMSS) in 151 patients with early-stage Parkinson's disease who had undergone a dopamine transporter PET scan as an initial diagnostic procedure. We classified the patients into two groups; high non-motor patients (HNM-PD; K-NMSS score ≥ 41) and low non-motor patients (LNM-PD). RESULTS: Patients in the HNM-PD group (n = 71) were older, had longer symptom duration, exhibited more severe motor deficits, and had been prescribed higher levodopa-equivalent doses at follow-up than those in the LNM-PD group. However, dopamine transporter binding to the striatal sub-regions and inter-sub-regional binding ratios were comparable between the two groups. A general linear model showed that the HNM-PD group had significantly more severe motor deficits than the LNM-PD group after controlling for age, gender, symptom duration, and dopamine transporter binding to the sensorimotor striatum. CONCLUSIONS: This study demonstrated that the pattern of striatal dopamine depletion does not contribute to early non-motor burden in Parkinson's disease. Our results suggest that LNM-PD patients may have a more benign course of motor symptom progression than HNM-PD patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHDisease Progression-
dc.subject.MESHDopamine/deficiency*-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMotor Activity-
dc.subject.MESHNeostriatum/metabolism*-
dc.subject.MESHParkinson Disease/diagnostic imaging-
dc.subject.MESHParkinson Disease/metabolism*-
dc.subject.MESHParkinson Disease/physiopathology-
dc.subject.MESHPositron Emission Tomography Computed Tomography-
dc.subject.MESHPositron-Emission Tomography-
dc.titleStriatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorSu Jin Chung-
dc.contributor.googleauthorJae Jung Lee-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorByoung Seok Ye-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.identifier.doi10.1371/journal.pone.0161316-
dc.contributor.localIdA04603-
dc.contributor.localIdA03082-
dc.contributor.localIdA03270-
dc.contributor.localIdA04668-
dc.contributor.localIdA04338-
dc.contributor.localIdA01982-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27529171-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameYe, Byoung Seok-
dc.contributor.alternativeNameLee, Jae Jung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameChung, Su Jin-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.affiliatedAuthorYe, Byoung Seok-
dc.contributor.affiliatedAuthorLee, Jae Jung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorChung, Su Jin-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.citation.volume11-
dc.citation.number8-
dc.citation.startPagee0161316-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(8) : e0161316, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46182-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.