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Human Radiation Dosimetry of [(18)F]AV-1451(T807) to Detect Tau Pathology

Authors
 Jae Yong Choi  ;  Chul Hyoung Lyoo  ;  Jae Hoon Lee  ;  Hanna Cho  ;  Kyeong Min Kim  ;  Jin Su Kim  ;  Young Hoon Ryu 
Citation
 Molecular Imaging and Biology, Vol.18(4) : 479-482, 2016 
Journal Title
 Molecular Imaging and Biology 
ISSN
 1536-1632 
Issue Date
2016
MeSH
Carbolines/chemistry* ; Dose-Response Relationship, Radiation ; Female ; Fluorine Radioisotopes/chemistry* ; Humans ; Male ; Middle Aged ; Radiometry* ; Tauopathies/diagnosis* ; Tauopathies/diagnostic imaging* ; Time Factors ; Tissue Distribution ; Whole Body Imaging
Keywords
Dosimetry ; PET ; Tau ; [18F]AV-1451
Abstract
PURPOSE: [(18)F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [(18)F]AV-1451 in humans. PROCEDURES: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [(18)F]AV-1451 (268?±?31 MBq). Radiation doses were estimated using the OLINDA/EXM software. RESULTS: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47?±?3.59 μSv/MBq. CONCLUSIONS: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [(18)F]AV-1451 could be used in multiple PET scans of the same subject per year.
Full Text
http://link.springer.com/article/10.1007%2Fs11307-015-0924-7
DOI
10.1007/s11307-015-0924-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151817
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