Cited 14 times in
Human Radiation Dosimetry of [(18)F]AV-1451(T807) to Detect Tau Pathology
DC Field | Value | Language |
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dc.contributor.author | 류철형 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 조한나 | - |
dc.contributor.author | 최재용 | - |
dc.date.accessioned | 2017-10-26T07:16:10Z | - |
dc.date.available | 2017-10-26T07:16:10Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1536-1632 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151817 | - |
dc.description.abstract | PURPOSE: [(18)F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [(18)F]AV-1451 in humans. PROCEDURES: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [(18)F]AV-1451 (268?±?31 MBq). Radiation doses were estimated using the OLINDA/EXM software. RESULTS: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47?±?3.59 μSv/MBq. CONCLUSIONS: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [(18)F]AV-1451 could be used in multiple PET scans of the same subject per year. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | MOLECULAR IMAGING AND BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Carbolines/chemistry* | - |
dc.subject.MESH | Dose-Response Relationship, Radiation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorine Radioisotopes/chemistry* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Radiometry* | - |
dc.subject.MESH | Tauopathies/diagnosis* | - |
dc.subject.MESH | Tauopathies/diagnostic imaging* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tissue Distribution | - |
dc.subject.MESH | Whole Body Imaging | - |
dc.title | Human Radiation Dosimetry of [(18)F]AV-1451(T807) to Detect Tau Pathology | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Kyeong Min Kim | - |
dc.contributor.googleauthor | Jin Su Kim | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.identifier.doi | 10.1007/s11307-015-0924-7 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A03093 | - |
dc.contributor.localId | A03920 | - |
dc.contributor.localId | A04695 | - |
dc.contributor.localId | A01333 | - |
dc.relation.journalcode | J02887 | - |
dc.identifier.eissn | 1860-2002 | - |
dc.identifier.pmid | 26728162 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs11307-015-0924-7 | - |
dc.subject.keyword | Dosimetry | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | Tau | - |
dc.subject.keyword | [18F]AV-1451 | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.alternativeName | Cho, Hanna | - |
dc.contributor.alternativeName | Choi, Jae Yong | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Hanna | - |
dc.contributor.affiliatedAuthor | Choi, Jae Yong | - |
dc.contributor.affiliatedAuthor | Lyoo, Chul Hyoung | - |
dc.citation.volume | 18 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 482 | - |
dc.identifier.bibliographicCitation | MOLECULAR IMAGING AND BIOLOGY, Vol.18(4) : 479-482, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45826 | - |
dc.type.rims | ART | - |
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