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Tau PET in Alzheimer disease and mild cognitive impairment

 Hanna Cho  ;  Jae Yong Choi  ;  Mi Song Hwang  ;  Jae Hoon Lee  ;  You Jin Kim  ;  Hye Mi Lee  ;  Chul Hyoung Lyoo  ;  Young Hoon Ryu  ;  Myung Sik Lee 
 NEUROLOGY, Vol.87(4) : 375-383, 2016 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging* ; Alzheimer Disease/metabolism* ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/metabolism ; Aniline Compounds ; Atrophy ; Cognitive Dysfunction/diagnostic imaging* ; Cognitive Dysfunction/metabolism* ; Cognitive Dysfunction/psychology ; Disease Progression ; Entorhinal Cortex/diagnostic imaging ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Memory ; Neuropsychological Tests ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals ; Stilbenes ; Vision, Ocular ; tau Proteins/metabolism*
OBJECTIVE: To investigate the topographical distribution of tau pathology and its effect on functional and structural changes in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) by using (18)F-AV-1451 PET. METHODS: We included 20 patients with AD, 15 patients with MCI, and 20 healthy controls, and performed neuropsychological function tests, MRI, as well as (18)F-florbetaben (for amyloid) and (18)F-AV-1451 (for tau) PET scans. By using the regional volume-of-interest masks extracted from MRIs, regional binding values of standardized uptake value ratios and volumes were measured. We compared regional binding values among 3 diagnostic groups and identified correlations among the regional binding values, performance in each cognitive function test, and regional atrophy. RESULTS: (18)F-AV-1451 binding was increased only in the entorhinal cortex in patients with MCI, while patients with AD exhibited greater binding in most cortical regions. In the 35 patients with MCI and AD, (18)F-AV-1451 binding in most of the neocortex increased with a worsening of global cognitive function. The visual and verbal memory functions were associated with the extent of (18)F-AV-1451 binding, especially in the medial temporal regions. The (18)F-AV-1451 binding also correlated with the severity of regional atrophy of the cerebral cortex. CONCLUSIONS: Tau PET imaging with (18)F-AV-1451 could serve as an in vivo biomarker for the evaluation of AD-related tau pathology and monitoring disease progression. The accumulation of pathologic tau is more closely related to functional and structural deterioration in the AD spectrum than β-amyloid.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Hye Mi(이혜미)
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
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