0 117

Cited 6 times in

The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease

 Hye Won Lee  ;  Sook Hee Chung  ;  Chang Mo Moon  ;  Xiumei Che  ;  Seung Won Kim  ;  Soo Jung Park  ;  Sung Pil Hong  ;  Tae Il Kim  ;  Won Ho Kim  ;  Jae Hee Cheon 
 Medicine, Vol.95(23) : 3772-3772, 2016 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Biomarkers/blood ; Endoscopy, Gastrointestinal ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Inflammatory Bowel Diseases/blood* ; Inflammatory Bowel Diseases/diagnosis ; Interleukin-12 Subunit p40/biosynthesis* ; Interleukin-12 Subunit p40/blood ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Young Adult
Genetic variants in IL12B, encoding the p40 subunit common in interleukin-12 (IL-12) and interleukin-23, were identified as the susceptibility loci for inflammatory bowel disease (IBD). This study aimed to identify the correlation of serum IL-12B expression with disease activity in patients with IBD and evaluate the possibility of IL-12B as a biomarker for assessing inflammatory status in IBD.A total of 102 patients with IBD, including 38, 32, and 32 patients with Crohn's disease (CD), ulcerative colitis (UC), and intestinal Beh?et's disease (intestinal BD), respectively, were included. The clinical and laboratory data from the patients were collected at the time of serum IL-12B measurement. Serum IL-12B levels were measured using an enzyme-linked immunosorbent assay.The median IL-12B levels in patients with CD, UC, and intestinal BD were significantly higher than those in controls (1.87, 2.74, and 2.73?pg/mL, respectively, vs. 1.42?pg/mL, all P?<0.05). IL-12B concentrations were associated with disease activity in patients with UC and intestinal BD but not in those with CD. IL-12B levels were increased with increasing disease activity in patients with UC (P?<0.001). Likewise, patients with active intestinal BD had higher IL-12B levels than those without active disease (P = 0.008). IL-12B levels were correlated with the endoscopic disease activity of UC (P = 0.002) and intestinal BD (P = 0.001) but not that of CD.Serum IL-12B levels were significantly correlated with clinical and endoscopic disease activity in patients with UC and intestinal BD, suggesting its potential use as a biomarker for assessing disease activity in these patients.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김승원(Kim, Seung Won)
김원호(Kim, Won Ho)
김태일(Kim, Tae Il) ORCID logo https://orcid.org/0000-0003-4807-890X
박수정(Park, Soo Jung)
이혜원(Lee, Hye Won) ORCID logo https://orcid.org/0000-0002-3552-3560
천재희(Cheon, Jae Hee) ORCID logo https://orcid.org/0000-0002-2282-8904
홍성필(Hong, Sung Pil)
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.