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Forensic DNA methylation profiling from evidence material for investigative leads

Authors
 Hwan Young Lee  ;  Soong Deok Lee  ;  Kyoung-Jin Shin 
Citation
 BMB REPORTS, Vol.49(7) : 359-369, 2016 
Journal Title
BMB REPORTS
ISSN
 1976-6696 
Issue Date
2016
MeSH
Alcohol Drinking ; Body Fluids/metabolism ; CpG Islands ; DNA/genetics ; DNA/metabolism* ; DNA Methylation* ; Environmental Exposure ; Forensic Genetics ; Humans ; Smoking
Keywords
Age prediction ; Body fluid identification ; DNA methylation ; Forensic genetics ; Investigative lead
Abstract
DNA methylation is emerging as an attractive marker providing investigative leads to solve crimes in forensic genetics. The identification of body fluids that utilizes tissue-specific DNA methylation can contribute to solving crimes by predicting activity related to the evidence material. The age estimation based on DNA methylation is expected to reduce the number of potential suspects, when the DNA profile from the evidence does not match with any known person, including those stored in the forensic database. Moreover, the variation in DNA implicates environmental exposure, such as cigarette smoking and alcohol consumption, thereby suggesting the possibility to be used as a marker for predicting the lifestyle of potential suspect. In this review, we describe recent advances in our understanding of DNA methylation variations and the utility of DNA methylation as a forensic marker for advanced investigative leads from evidence materials.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Lee, Hwan Young(이환영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151750
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