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The thyroid imaging reporting and data system on US, but not the BRAFV600E mutation in fine-needle aspirates, is associated with lateral lymph node metastasis in PTC

DC Field Value Language
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author박영진-
dc.contributor.author윤정현-
dc.date.accessioned2017-10-26T07:12:08Z-
dc.date.available2017-10-26T07:12:08Z-
dc.date.issued2016-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151731-
dc.description.abstractThe majority of patients with papillary thyroid carcinoma (PTC) have an excellent prognosis, but some show poorer outcomes and would benefit from adjunctive prognostic tools. The B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation, either based on both its presence or its quantitative measurement, and ultrasound (US) features may serve as a prognostic marker. The aim of this study was to investigate (1) the association between clinical-pathologic prognostic factors and the BRAF mutation found in fine-needle aspirates, based on both its presence and its corresponding cycle threshold (Ct) value, and (2) the association between prognostic factors and suspicious US features classified by the thyroid imaging reporting and data system (TIRADS) in PTC.Two-hundred fifty-eight consecutive patients with PTC > 1?cm and who underwent preoperative US-guided fine-needle aspiration were included in this retrospective study. Clinical-pathologic variables were compared between patients with and without the BRAF mutation. Multivariate analyses were performed to investigate (1) the association between clinical-pathologic prognostic factors and the BRAF mutation found in fine-needle aspirates, based on both its presence and corresponding Ct values, and (2) the association between prognostic factors and suspicious TIRADS US features.BRAF-positive patients had a higher proportion of multiple tumors (P?=?0.017). The number of suspicious US features classified by the TIRADS was an independent factor for predicting lateral lymph node metastasis, both in all 258 patients (odds ratio [OR]?=?1.902, P?=?0.005) and in 214 BRAF-positive patients (OR?=?1.686, P?=?0.037). The BRAF mutation status or BRAFCt values were not associated with any of the clinical-pathologic prognostic factors.In conclusion, a higher number of suspicious US features classified by the TIRADS, but not the BRAF mutation, are associated with lateral lymph node metastasis in patients with PTC, and can aid in the preoperative identification of patients at increased risk of lateral lymph node metastasis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlleles-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHCarcinoma, Papillary/diagnostic imaging*-
dc.subject.MESHCarcinoma, Papillary/genetics*-
dc.subject.MESHCarcinoma, Papillary/pathology-
dc.subject.MESHDNA Mutational Analysis*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymph Nodes/pathology-
dc.subject.MESHLymphatic Metastasis/genetics*-
dc.subject.MESHLymphatic Metastasis/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation/genetics*-
dc.subject.MESHNeoplasms, Multiple Primary/diagnostic imaging-
dc.subject.MESHNeoplasms, Multiple Primary/genetics-
dc.subject.MESHNeoplasms, Multiple Primary/pathology-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins B-raf/genetics*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStatistics as Topic-
dc.subject.MESHThyroid Gland/diagnostic imaging-
dc.subject.MESHThyroid Neoplasms/diagnostic imaging*-
dc.subject.MESHThyroid Neoplasms/genetics*-
dc.subject.MESHThyroid Neoplasms/pathology-
dc.subject.MESHUltrasonography, Interventional-
dc.subject.MESHYoung Adult-
dc.titleThe thyroid imaging reporting and data system on US, but not the BRAFV600E mutation in fine-needle aspirates, is associated with lateral lymph node metastasis in PTC-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorVivian Y. Park-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorJin Young Kwak-
dc.identifier.doi10.1097/MD.0000000000004292-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA01572-
dc.contributor.localIdA02595-
dc.contributor.localIdA00182-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid27442672-
dc.subject.keywordBRAFV600E mutation-
dc.subject.keywordlateral lymph node metastasis-
dc.subject.keywordpapillary thyroid carcinoma-
dc.subject.keywordthyroid imaging reporting and data system-
dc.subject.keywordultrasound-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNamePark, Vivian Young Jean-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorPark, Vivian Youngjean-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.citation.volume95-
dc.citation.number29-
dc.citation.startPage4292-
dc.identifier.bibliographicCitationMEDICINE, Vol.95(29) : 4292, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid45744-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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