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Cited 21 times in

Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy

DC FieldValueLanguage
dc.contributor.author금웅섭-
dc.contributor.author정재호-
dc.contributor.author김현기-
dc.contributor.author정현수-
dc.contributor.author김형일-
dc.contributor.author정현철-
dc.contributor.author김효송-
dc.contributor.author최윤영-
dc.contributor.author노성훈-
dc.contributor.author형우진-
dc.contributor.author라선영-
dc.contributor.author박준철-
dc.contributor.author범승훈-
dc.contributor.author손태일-
dc.contributor.author신상준-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author임준석-
dc.contributor.author정민규-
dc.date.accessioned2017-10-26T07:10:48Z-
dc.date.available2017-10-26T07:10:48Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151703-
dc.description.abstractGastric cancer (GC) is a leading cause of death. We aim to establish a clinically relevant assay that encompasses recent molecular classifications and provides useful clinical information in a large cohort of GC patients. A consecutive series of 438 GC patients that underwent palliative chemotherapy between 2014 and 2015 were assessed using 10 GC panels: EBER in-situ hybridization, immunohistochemistry for mismatch repair (MMR) proteins (MLH1, PMS2, MSH2, and MSH6), receptor tyrosine kinases (RTKs; HER2, EGFR, and MET), PTEN, and p53 protein. With a median of one aberration, 3.3 % of samples analyzed were Epstein-Barr virus (EBV)-positive; 4.8%, MMR-deficient. RTKs were overexpressed in 218 patients; EGFR was most commonly overexpressed (39.9%), followed by HER2 (13.5%) and MET (12.1%). Furthermore, 2.5 % and 10.7 % of cases had simultaneous overexpression of three and two RTKs, respectively. p53 overexpression/null tumors were identified in 259 patients (59.1%), and PTEN loss was identified in 89 patients (20.3%). EBV-positivity was mutually exclusive with MMR-deficiency, predominantly identified in male patients, and these tumors were undifferentiated with proximal location. p53 mutant type was significantly found predominantly in the EBV-negative (60.6% vs 14.3%, P=0.001) and HER2-positive (78.0% vs 56.2%, P=0.002) groups. We described a molecular spectrum of distinct GC subtypes using clinically applicable assay. This assay will provide a convenient screening tool and facilitate the development of targeted agents in clinical trials.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHCohort Studies-
dc.subject.MESHEpstein-Barr Virus Infections/drug therapy-
dc.subject.MESHEpstein-Barr Virus Infections/metabolism*-
dc.subject.MESHEpstein-Barr Virus Infections/virology-
dc.subject.MESHFemale-
dc.subject.MESHHerpesvirus 4, Human/genetics-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry/methods*-
dc.subject.MESHIn Situ Hybridization-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPTEN Phosphohydrolase/metabolism-
dc.subject.MESHRNA, Viral/genetics-
dc.subject.MESHStomach Neoplasms/drug therapy-
dc.subject.MESHStomach Neoplasms/metabolism*-
dc.subject.MESHStomach Neoplasms/virology-
dc.subject.MESHTumor Suppressor Protein p53/metabolism-
dc.subject.MESHYoung Adult-
dc.titleComprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorSu-Jin Shin-
dc.contributor.googleauthorSeung-Hoon Beom-
dc.contributor.googleauthorMinkyu Jung-
dc.contributor.googleauthorYoon Young Choi-
dc.contributor.googleauthorTaeil Son-
dc.contributor.googleauthorHyoung-Il Kim-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyunsoo Chung-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorJoon Seok Lim-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyunki Kim-
dc.identifier.doi10.18632/oncotarget.10115-
dc.contributor.localIdA03717-
dc.contributor.localIdA01108-
dc.contributor.localIdA03765-
dc.contributor.localIdA01154-
dc.contributor.localIdA03773-
dc.contributor.localIdA01202-
dc.contributor.localIdA04138-
dc.contributor.localIdA01281-
dc.contributor.localIdA04382-
dc.contributor.localIdA01316-
dc.contributor.localIdA01676-
dc.contributor.localIdA04581-
dc.contributor.localIdA01998-
dc.contributor.localIdA02105-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03408-
dc.contributor.localIdA03606-
dc.contributor.localIdA00273-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid27331626-
dc.subject.keywordgastric cancer-
dc.subject.keywordimmunohistochemistry-
dc.subject.keywordin-situ hybridization-
dc.subject.keywordmolecular subtypes-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.alternativeNameKim, Hyoung Il-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameChoi, Yoon Young-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameBeum, Seung Hoon-
dc.contributor.alternativeNameSon, Tae Il-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLim, Joon Seok-
dc.contributor.alternativeNameJung, Min Kyu-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorChung, Hyun Soo-
dc.contributor.affiliatedAuthorKim, Hyoung Il-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorChoi, Yoon Young-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorBeum, Seung Hoon-
dc.contributor.affiliatedAuthorSon, Tae Il-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLim, Joon Seok-
dc.contributor.affiliatedAuthorJung, Min Kyu-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.citation.volume7-
dc.citation.number28-
dc.citation.startPage44608-
dc.citation.endPage44620-
dc.identifier.bibliographicCitationONCOTARGET , Vol.7(28) : 44608-44620, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid45717-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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