Cited 42 times in
Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 정현수 | - |
dc.contributor.author | 김형일 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 최윤영 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 형우진 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박준철 | - |
dc.contributor.author | 범승훈 | - |
dc.contributor.author | 손태일 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 신성관 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 임준석 | - |
dc.contributor.author | 정민규 | - |
dc.date.accessioned | 2017-10-26T07:10:48Z | - |
dc.date.available | 2017-10-26T07:10:48Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151703 | - |
dc.description.abstract | Gastric cancer (GC) is a leading cause of death. We aim to establish a clinically relevant assay that encompasses recent molecular classifications and provides useful clinical information in a large cohort of GC patients. A consecutive series of 438 GC patients that underwent palliative chemotherapy between 2014 and 2015 were assessed using 10 GC panels: EBER in-situ hybridization, immunohistochemistry for mismatch repair (MMR) proteins (MLH1, PMS2, MSH2, and MSH6), receptor tyrosine kinases (RTKs; HER2, EGFR, and MET), PTEN, and p53 protein. With a median of one aberration, 3.3 % of samples analyzed were Epstein-Barr virus (EBV)-positive; 4.8%, MMR-deficient. RTKs were overexpressed in 218 patients; EGFR was most commonly overexpressed (39.9%), followed by HER2 (13.5%) and MET (12.1%). Furthermore, 2.5 % and 10.7 % of cases had simultaneous overexpression of three and two RTKs, respectively. p53 overexpression/null tumors were identified in 259 patients (59.1%), and PTEN loss was identified in 89 patients (20.3%). EBV-positivity was mutually exclusive with MMR-deficiency, predominantly identified in male patients, and these tumors were undifferentiated with proximal location. p53 mutant type was significantly found predominantly in the EBV-negative (60.6% vs 14.3%, P=0.001) and HER2-positive (78.0% vs 56.2%, P=0.002) groups. We described a molecular spectrum of distinct GC subtypes using clinically applicable assay. This assay will provide a convenient screening tool and facilitate the development of targeted agents in clinical trials. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Epstein-Barr Virus Infections/drug therapy | - |
dc.subject.MESH | Epstein-Barr Virus Infections/metabolism* | - |
dc.subject.MESH | Epstein-Barr Virus Infections/virology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Herpesvirus 4, Human/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry/methods* | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | PTEN Phosphohydrolase/metabolism | - |
dc.subject.MESH | RNA, Viral/genetics | - |
dc.subject.MESH | Stomach Neoplasms/drug therapy | - |
dc.subject.MESH | Stomach Neoplasms/metabolism* | - |
dc.subject.MESH | Stomach Neoplasms/virology | - |
dc.subject.MESH | Tumor Suppressor Protein p53/metabolism | - |
dc.subject.MESH | Young Adult | - |
dc.title | Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Su-Jin Shin | - |
dc.contributor.googleauthor | Seung-Hoon Beom | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Yoon Young Choi | - |
dc.contributor.googleauthor | Taeil Son | - |
dc.contributor.googleauthor | Hyoung-Il Kim | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Woo Jin Hyung | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Hyunsoo Chung | - |
dc.contributor.googleauthor | Jun Chul Park | - |
dc.contributor.googleauthor | Sung Kwan Shin | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.identifier.doi | 10.18632/oncotarget.10115 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A03765 | - |
dc.contributor.localId | A01154 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A04138 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A04382 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A01676 | - |
dc.contributor.localId | A04581 | - |
dc.contributor.localId | A01998 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02112 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A03408 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A00273 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27331626 | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | in-situ hybridization | - |
dc.subject.keyword | molecular subtypes | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Chung, Hyun Soo | - |
dc.contributor.alternativeName | Kim, Hyoung Il | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Choi, Yoon Young | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Park, Jun Chul | - |
dc.contributor.alternativeName | Beum, Seung Hoon | - |
dc.contributor.alternativeName | Son, Tae Il | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Shin, Sung Kwan | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Lim, Joon Seok | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Soo | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Il | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Choi, Yoon Young | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Park, Jun Chul | - |
dc.contributor.affiliatedAuthor | Beum, Seung Hoon | - |
dc.contributor.affiliatedAuthor | Son, Tae Il | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Shin, Sung Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Lim, Joon Seok | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.citation.volume | 7 | - |
dc.citation.number | 28 | - |
dc.citation.startPage | 44608 | - |
dc.citation.endPage | 44620 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, Vol.7(28) : 44608-44620, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45717 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.