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A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation

Authors
 Seong Jun Ryu  ;  Jong Yul Kim  ;  Kyung Hyun Kim  ;  Jeong Yoon Park  ;  Sung Uk Kuh  ;  Dong Kyu Chin  ;  Keun Su Kim  ;  Yong Eun Cho  ;  Se Hoon Kim 
Citation
 European Spine Journal, Vol.25(12) : 4067-4079, 2016 
Journal Title
 European Spine Journal 
ISSN
 0940-6719 
Issue Date
2016
MeSH
Adolescent ; Adult ; Aged ; Astrocytoma/complications ; Astrocytoma/pathology ; Astrocytoma/surgery* ; Back Pain/etiology ; Disease Progression ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nervous System Diseases/etiology ; Neurosurgical Procedures*/methods ; Prognosis ; Retrospective Studies ; Risk Factors ; Spinal Cord Neoplasms/complications ; Spinal Cord Neoplasms/pathology ; Spinal Cord Neoplasms/surgery* ; Treatment Outcome ; Young Adult
Keywords
Astrocytoma ; Malignant glioma ; Radiotherapy ; Spinal cord neoplasm ; Survival
Abstract
PURPOSE: To determine the biologic behavior and prognostic factors of spinal cord astrocytoma, we reviewed surgical and clinical outcomes. Due to the rarity of spinal cord astrocytoma, there is a lack of research regarding this type of tumor and malignant transformation. METHODS: We retrospectively reviewed the data from all patients on whom we performed spinal cord tumor removal between 1983 and 2014. Twenty-six patients were pathologically confirmed to have spinal cord astrocytoma or glioblastoma. Surgical extent and disease progression were confirmed by the surgeon based on operative findings, postoperative MRI, and outpatient department (OPD) follow-up. RESULTS: Pain or neurological deficit was the chief complaint for all patients. With MRI studies, there is a tendency for high-grade astrocytomas to show as enhanced and heterogeneous images. Two of the low-grade astrocytomas showed malignant transformation over the course of 4 and 11 months, respectively. The overall survival (OS) for low-grade astrocytoma was 28-480 months (mean 156.38 months); the OS for high-grade astrocytoma was 1-36 months (mean 12.00 months). CONCLUSIONS: Two of 12 low-grade cases showed malignant transformations at 4 and 11 months, respectively, based on pathological confirmation. With spinal cord astrocytomas, enhanced MRI results appeared similar to those of a malignant lesion. We suggest close observation and image correlation of low-grade astrocytomas, even when pathologically confirmed as low-grade. In this review, we found that histologic grade is the most important prognostic factor, although it is not always concordant with biologic behaviors.
Full Text
http://link.springer.com/article/10.1007%2Fs00586-016-4475-7
DOI
10.1007/s00586-016-4475-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
구성욱(Kuh, Sung Uk) ORCID logo https://orcid.org/0000-0003-2566-3209
김경현(Kim, Kyung Hyun)
김근수(Kim, Keun Su) ORCID logo https://orcid.org/0000-0002-3384-5638
김세훈(Kim, Se Hoon) ORCID logo https://orcid.org/0000-0001-7516-7372
박정윤(Park, Jeong Yoon) ORCID logo https://orcid.org/0000-0002-3728-7784
조용은(Cho, Yong Eun) ORCID logo https://orcid.org/0000-0001-9815-2720
진동규(Chin, Dong Kyu) ORCID logo https://orcid.org/0000-0002-9835-9294
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151694
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