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Emergence and Wide Dissemination of CTX-M-type ESBLs, and CMY-2- and DHA-1-type AmpC β-Lactamases in Korean Respiratory Isolates of Klebsiella pneumoniae

Authors
 Jong Hwa Yum  ;  Shinyoung Kim  ;  Hyukmin Lee  ;  Dongeun Yong  ;  Kyungwon Lee  ;  Sang-Nae Cho  ;  Yunsop Chong 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.20(6) : 961-965, 2005 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2005
MeSH
beta-lactamase CTX-M-14 ; beta-lactamase CMY-2 ; beta-lactamase DHA-1 ; AmpC beta-lactamase ; Klebsiella pneumoniae
Keywords
beta-lactamase CTX-M-14 ; beta-lactamase CMY-2 ; beta-lactamase DHA-1 ; AmpC beta-lactamase ; Klebsiella pneumoniae
Abstract
Respiratory isolates of Klebsiella pneumoniae in Korea during 2002-2003 were studied to determine the prevalence and types of extended-spectrum β-lactamases (ESBLs) and plasmid-mediated AmpC β-lactamases (PABLs). ESBL-production was tested by double-disk synergy, and genotypes of β-lactamases were determined by PCR and sequencing. ESBLs were detected in 28.4% of 373 isolates, and the most prevalent types were SHV-12 (63 isolates) and CTX-M-14 (9 isolates). Forty of 75 ESBL-producers (53.5%) also had PABLs: 21 isolates with CMY-2-like, 17 with DHA-1-like. Pulsed-field gel electrophoresis showed 19 types and 25 of 74 isolates had an identical pattern, indicating nosocomial spread. Dissemination of ESBL- and PABL-producing K. pneumoniae strains in Korea is a particular concern, as it limits the choice of antimicrobial agents for treatment of infections.
Files in This Item:
T200501501.pdf Download
DOI
10.3346/jkms.2005.20.6.961
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Hyuk Min(이혁민) ORCID logo https://orcid.org/0000-0002-8523-4126
Chong, Yun Sop(정윤섭)
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151499
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