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The effect of methylenetetrahydrofolate reductase polymorphism C677T on cervical cancer in Korean women

 Jae Woong Sull  ;  Sun Ha Jee  ;  Sangwook Yi  ;  Jong Eun Lee  ;  Jong Sup Park  ;  Sook Kim  ;  Heechoul Ohrr 
 GYNECOLOGIC ONCOLOGY, Vol.95(3) : 557-563, 2004 
Journal Title
Issue Date
Adult ; Aged ; Alleles ; CervicalIntraepithelial Neoplasia/enzymology ; CervicalIntraepithelial Neoplasia/genetics ; CervicalIntraepithelial Neoplasia/virology ; Female ; GeneticPredisposition to Disease ; Humans ; Methylenetetrahydrofolate Reductase(NADPH2)/genetics* ; Middle Aged ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/enzymology ; Polymorphism, Genetic ; Risk Factors ; Uterine Cervical Neoplasms/enzymology* ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/virology
OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) gene is associated with DNA hypomethylation, an established hallmark of human cancer cells. The aim of this study was to examine the effect of MTHFR polymorphism C677T on cervical carcinogenesis in the context of other environmental factors, such as smoking, parity, and age at the first intercourse.
METHODS: The study subjects were patients who were pathologically diagnosed with cervical neoplasia and who had a positive result for human papillomavirus (N = 462), and they were compared to normal healthy women as normal controls (N = 454). Genotypes of the patients and control samples were assayed by single base primer extension assay using SNapShot assay kit.
RESULTS: Compared with MTHFR C/C, the odds ratio (95% confidence interval) for MTHFR T/T was 1.4 (0.9-2.3) for invasive cervical cancer and 1.3 (0.8-2.3) for cervical intraepithelial neoplasia (CIN) II or III. The risks for invasive cervical cancer were higher with less than 40 years old at diagnosis (2.1, 1.0-4.3), than with over 40 years old at diagnosis (1.2, 0.7-2.2). Current smoking women with early onset with MTHFR T/T had a 4.7 (0.6-36.2) times higher risk of cervical cancer. The risks of MTHFR T/T or C/T also increased for women with an early age of first intercourse or for women with two or more children, as compared with MTHFR C/C.
CONCLUSION: Polymorphisms of MTHFR are associated with a higher risk of developing cervical cancer, and in particular for an early onset of cervical carcinogenesis.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Ohrr, Hee Choul(오희철)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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