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“Off” gait freezing and temporal discrimination threshold in patients with Parkinson disease

Authors
 Myung-Sik Lee  ;  Hyun-Sook Kim  ;  Chul-Hyoung Lyoo 
Citation
 NEUROLOGY, Vol.64(4) : 670-674, 2005 
Journal Title
 NEUROLOGY 
ISSN
 0028-3878 
Issue Date
2005
MeSH
Aged ; Antiparkinson Agents/administration & dosage ; Antiparkinson Agents/therapeutic use ; Female ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology* ; Humans ; Levodopa/administration & dosage ; Levodopa/therapeutic use ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Parkinson Disease/physiopathology* ; Perceptual Disorders/drug therapy ; Perceptual Disorders/etiology ; Perceptual Disorders/physiopathology* ; Posture ; Reflex, Abnormal ; Sensory Thresholds/physiology* ; Somatosensory Disorders/drug therapy ; Somatosensory Disorders/etiology ; Somatosensory Disorders/physiopathology* ; Time Perception* ; Toes/physiopathology ; Touch
Keywords
15728290
Abstract
OBJECTIVE: To investigate the relationship between temporal discrimination threshold (TDT) and "off" period gait freezing (OGF) in patients with fluctuating Parkinson disease (PD). METHODS: TDT values were measured at the dorsum of the toes in 11 control subjects and 22 patients with PD with a wearing-off phenomenon (16 patients with OGF and 6 patients without OGF). RESULTS: During the l-dopa "off" period, TDT values increased abnormally in both patient groups but were significantly higher in patients with OGF than in those without OGF. A positive correlation was found between the severity of OGF and TDT values measured by different point stimulation. In patients with OGF, a single dose of l-dopa treatment normalized TDT values and ameliorated OGF. CONCLUSIONS: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of "off" period gait freezing observed in patients with fluctuating Parkinson disease.
Full Text
http://www.neurology.org/content/64/4/670.long
DOI
10.1212/01.WNL.0000151961.14861.BA
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Sook(김현숙)
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151383
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