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중증근무력증과 인터루킨-1β, 인터루킨-1 수용체 길항제 유전자 다형성의 연관성 : 예비연구

Other Titles
 IL-1β and IL-1 Receptor Antagonist Gene Polymorphisms in Myasthenia Gravis 
Authors
 박지형  ;  김현숙  ;  김원주  ;  김대성  ;  최영철 
Citation
 Journal of the Korean Neurological Association, Vol.23(4) : 484-489, 2005 
Journal Title
 Journal of the Korean Neurological Association 
ISSN
 1738-1428 
Issue Date
2005
MeSH
IL-1β ; IL-1 receptor antagonist ; myasthenia gravis ; 인터루킨-1β ; 인터루킨-1 수용체 길항제 ; 중증 근무력증
Keywords
IL-1β ; IL-1 receptor antagonist ; myasthenia gravis ; 인터루킨-1β ; 인터루킨-1 수용체 길항제 ; 중증 근무력증
Abstract
Background: Myasthenia gravis (MG) is an autoimmune disorder characterized by an immune response against the nicotinic acetylcholine receptor at the neuromuscular junction. Genetic factors as well as abnormalities of immune regulation can increase the likelihood of MG. Proinflammatory cytokines interleukin (IL)-1α, IL-1β, and their receptor antagonist (IL-1Ra) play major roles in initiating and modulating immune responses. The aim of the present study was to analyze IL-1β and IL-1 Ra gene polymorphisms between MG patients and healthy controls. Methods: TaqI restriction fragment polymorphism (RFLP) in exon 5 of IL-1β and variable numbers of an 86-bp tandem repeat (VNTR) in intron 2 of IL-1Ra were analyzed in 80 patients with MG and 94 matched healthy control individuals. Results: In IL-1β TaqI RFLP, the genotype of A1/A1 and A1/A2 were 92.5% and 7.5% in patients with MG. In healthy controls, the frequencies of each genotype were 93.6% and 6.4% respectively. IL-1Ra polymorphism, the genotypes of A1/A1, A1/A2 and A1/A3 were 81.3%, 16.3%, and 2.5% in patients with MG. In healthy controls, the frequencies of each genotype were 87.2%, 7.4% and 3.2% respectively. There was no significant difference in the genotype frequencies of IL-1β TaqI RFLP and IL-1Ra polymorphism between patients and the control group. Conclusions: These data suggested that the IL-1β and IL-1Ra gene polymorphisms may not be associated with MG. However, further study is needed to clarify the possible role of IL-1β and IL-1Ra gene polymorphisms in the susceptibility to myasthenia gravis.
Files in This Item:
T200501222.pdf Download
DOI
OAK-2005-05752
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151382
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