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난소암에서 cyclin B1 및 D1 발현과 임상 예후 인자들과의 관련성

Other Titles
 Relationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma 
Authors
 김희연  ;  김재욱  ;  김영태  ;  강명화  ;  김재훈  ;  김성훈  ;  김상운  ;  윤보성 
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.48(11) : 2670-2681, 2005 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회지)
ISSN
 1738-5628 
Issue Date
2005
MeSH
Ovarian carcinoma ; Cyclin B1 ; Cyclin D1 ; Prognostic factors
Keywords
Ovarian carcinoma ; Cyclin B1 ; Cyclin D1 ; Prognostic factors
Abstract
Objective: The objective of this study was to evaluate the relationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma.

Methods: In this study, fresh ovarian tissue samples were obtained from 41 patients treated surgically at our institute from March of 2002 to February of 2005. These included 36 ovarian carcinomas and 5 normal ovarian tissues that were served as the control. Quantitative real-time RT-PCR and Western blot analysis were used in detecting the expression of mRNA and protein of cyclin B1, D1, respectively.

Results: The mean 2(-delta delta CT) values of cyclin B1 and D1 mRNA in ovarian carcinoma tissues obtained through quantitative real-time RT-PCR were 5.83+/-12.03, 17.60+/-22.20, respectively, and the mean values in the control were 0.55+/-0.35, 0.50+/-0.26, respectively. The results showed difference in the expression, but were not statistically significant (p=0.67, 0.07, respectively). If the mean densitometer value of cyclin B1 and D1 protein in the control obtained by Western blot analysis was 1, the mean values in ovarian carcinoma tissues were higher, but were not statistically significant (1.30+/-0.73, 1.81+/-1.28, respectively) (p=0.76, 0.06, respectively). The expression of cyclin B1, D1 and various prognostic factors was not statistically related.

Conclusion: Our results showed that the expression of cyclin B1 and D1 in ovarian carcinoma tissues was higher than in the normal control. This suggested that cyclin B1, D1 and the tumorigenesis and the degree of malignancy was closely related. But the expression of cyclin B1, D1 and various prognostic factors was not statistically related. Further studies based on the correlation between cyclin and response to treatment or survival rate are needed to support cyclin as a prognostic factor of ovarian carcinoma.
Files in This Item:
T200501274.pdf Download
DOI
OAK-2005-05853
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Yoon, Bo Sung(윤보성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151308
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