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난소암에서 cyclin B1 및 D1 발현과 임상 예후 인자들과의 관련성

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dc.contributor.author김상운-
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김재욱-
dc.contributor.author김재훈-
dc.contributor.author윤보성-
dc.date.accessioned2017-10-26T06:47:47Z-
dc.date.available2017-10-26T06:47:47Z-
dc.date.issued2005-
dc.identifier.issn1738-5628-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151308-
dc.description.abstractObjective: The objective of this study was to evaluate the relationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma. Methods: In this study, fresh ovarian tissue samples were obtained from 41 patients treated surgically at our institute from March of 2002 to February of 2005. These included 36 ovarian carcinomas and 5 normal ovarian tissues that were served as the control. Quantitative real-time RT-PCR and Western blot analysis were used in detecting the expression of mRNA and protein of cyclin B1, D1, respectively. Results: The mean 2(-delta delta CT) values of cyclin B1 and D1 mRNA in ovarian carcinoma tissues obtained through quantitative real-time RT-PCR were 5.83+/-12.03, 17.60+/-22.20, respectively, and the mean values in the control were 0.55+/-0.35, 0.50+/-0.26, respectively. The results showed difference in the expression, but were not statistically significant (p=0.67, 0.07, respectively). If the mean densitometer value of cyclin B1 and D1 protein in the control obtained by Western blot analysis was 1, the mean values in ovarian carcinoma tissues were higher, but were not statistically significant (1.30+/-0.73, 1.81+/-1.28, respectively) (p=0.76, 0.06, respectively). The expression of cyclin B1, D1 and various prognostic factors was not statistically related. Conclusion: Our results showed that the expression of cyclin B1 and D1 in ovarian carcinoma tissues was higher than in the normal control. This suggested that cyclin B1, D1 and the tumorigenesis and the degree of malignancy was closely related. But the expression of cyclin B1, D1 and various prognostic factors was not statistically related. Further studies based on the correlation between cyclin and response to treatment or survival rate are needed to support cyclin as a prognostic factor of ovarian carcinoma.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한산부인과학회-
dc.relation.isPartOfKorean Journal of Obstetrics and Gynecology (대한산부인과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHOvarian carcinoma-
dc.subject.MESHCyclin B1-
dc.subject.MESHCyclin D1-
dc.subject.MESHPrognostic factors-
dc.title난소암에서 cyclin B1 및 D1 발현과 임상 예후 인자들과의 관련성-
dc.title.alternativeRelationship between the expression of cyclin B1, D1 and the various prognostic factors in ovarian carcinoma-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthor김희연-
dc.contributor.googleauthor김재욱-
dc.contributor.googleauthor김영태-
dc.contributor.googleauthor강명화-
dc.contributor.googleauthor김재훈-
dc.contributor.googleauthor김성훈-
dc.contributor.googleauthor김상운-
dc.contributor.googleauthor윤보성-
dc.identifier.doiOAK-2005-05853-
dc.contributor.localIdA00526-
dc.contributor.localIdA00526-
dc.contributor.localIdA00595-
dc.contributor.localIdA00729-
dc.contributor.localIdA00866-
dc.contributor.localIdA00876-
dc.contributor.localIdA02554-
dc.relation.journalcodeJ02076-
dc.relation.journalsince1958~2004-
dc.relation.journalafter2005~ Korean Journal of Obstetrics and Gynecology (대한산부인과학회지)-
dc.subject.keywordOvarian carcinoma-
dc.subject.keywordCyclin B1-
dc.subject.keywordCyclin D1-
dc.subject.keywordPrognostic factors-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Jae Wook-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.alternativeNameYoon, Bo Sung-
dc.contributor.affiliatedAuthor김상운-
dc.citation.volume48-
dc.citation.number11-
dc.citation.startPage2670-
dc.citation.endPage2681-
dc.identifier.bibliographicCitationKorean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.48(11) : 2670-2681, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid44028-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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