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한국인 HIV 감염자에서 항레트로바이러스 치료이행도와 바이러스학적 치료 실패의 상관관계

Other Titles
 Correlation between Adherence to Antiretroviral Treatment and Virologic Failure in HIV-infected Koreans 
 최준용  ;  박윤수  ;  김창오  ;  박윤선  ;  윤희정  ;  신소연  ;  김연아  ;  송영구  ;  김준명 
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.37(1) : 9-15, 2005 
Journal Title
Issue Date
HIV ; HIV infection ; Acquired immunodeficiency syndrome ; Highly active antiretroviral therapy ; Adherence
HIV ; HIV infection ; Acquired immunodeficiency syndrome ; Highly active antiretroviral therapy ; Adherence
BACKGROUND: Several factors associated with human virologic failure in patients with immunodeficiency virus (HIV) infection are low CD4+ cell counts, advanced clinical stage, poor subscribing, subtherapeutic drug levels, etc. Among these factors, poor adherence is one of the leading causes. MATERIALS AND METHODS: We evaluated the adherence to antiretroviral treatment in HIV infected Koreans using questionnaire. We evaluated the factors associated with poor adherence and analyzed the correlation between the adherence to antiretroviral treatment and virologic failure. RESULTS: A total of 49 patients responded to the questionnaire. Of the 49 patients, 26 (53.1%) answered that they had never forgotten to take their medicine, and 23 (46.9%) answered that they had taken all their medications during the last week. The reasons for missed doses were forgetting, being too busy, having adverse side effects, etc. Low CD4+ T cell counts, longer duration of antiretroviral treatment, and longer duration of being diagnosed with HIV infection were associated with poor adherence in HIV infected Koreans (P<0.05). There was correlation between poor adherence and virologic failure in these HIV-infected Koreans (P<0.05). CONCLUSION: Because poor adherence induces treatment failure, monitoring adherence is very important for successful antiretroviral treatment. Questionnaire was a good method for monitoring adherence in HIV infected patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yeon A(김연아)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Park, Yoon Seon(박윤선)
Park, Yoon Soo(박윤수)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Shin, So Youn(신소연)
Yoon, Hee Jung(윤희정)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
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