0 330

Cited 22 times in

Roles of estrogen receptor, progesterone receptor, p53 and p21 in pathogenesis of pelvic organ prolapse

Authors
 Sang Wook Bai  ;  Da Jung Chung  ;  Jung Mi Yoon  ;  Jong Seung Shin  ;  Sei Kwang Kim  ;  Ki Hyun Park 
Citation
 INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol.16(6) : 492-496, 2005 
Journal Title
INTERNATIONAL UROGYNECOLOGY JOURNAL
ISSN
 0937-3462 
Issue Date
2005
MeSH
Aged ; Blotting, Western ; Cyclin-Dependent Kinase Inhibitor p21/metabolism* ; Female ; Humans ; Middle Aged ; Receptors, Estrogen/metabolism* ; Receptors, Progesterone/metabolism* ; Tumor Suppressor Protein p53/metabolism* ; Uterine Prolapse/etiology* ; Uterine Prolapse/metabolism
Keywords
ER ; PR ; p53 ; p21 ; Pathogenesis of POP
Abstract
The aim of this study is to compare the levels of estrogen receptor (ER), progesterone receptor (PR), p53 and p21 between pelvic organ prolapse (POP) and control groups in order to evaluate their roles in pathogenesis of POP, and to find out the relationship among these proteins. Through the year of 2002, uterosacral ligaments were obtained from 20 prolapsus and 24 non-prolapsus hysterectomized uteruses. ER, PR, p53, and p21 proteins were extracted by Western blot analysis and relative levels of proteins were compared by Student t-test and Pearson correlation coefficient. P value <0.05 was considered statistically significant. All patients were postmenopausal and had never taken hormone replacement therapy. ER, PR, p53, and p21 were significantly lower in the study than control group (p<0.0001). Positive correlations were found among all proteins in the prolapse group. Further researches are needed to elucidate the interrelationship among these proteins and their precise roles in pathogenesis of POP.
Full Text
http://link.springer.com/article/10.1007/s00192-005-1310-9
DOI
10.1007/s00192-005-1310-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sei Kwang(김세광)
Park, Ki Hyun(박기현)
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
Chung, Da Jung(정다정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151240
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links