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Obsessive-Compulsive Disorder, Factor-Analyzed Symptom Dimensions and Serotonin Transporter Polymorphism

Authors
 Kim S.J.  ;  Lee H.S.  ;  Kim C.-H. 
Citation
 NEUROPSYCHOBIOLOGY, Vol.52(4) : 176-182, 2005 
Journal Title
NEUROPSYCHOBIOLOGY
ISSN
 0302-282X 
Issue Date
2005
MeSH
Adult ; DNA/blood ; DNA Primers/genetics ; Factor Analysis, Statistical ; Female ; Genotype ; Humans ; Male ; Obsessive-Compulsive Disorder/diagnosis* ; Obsessive-Compulsive Disorder/genetics* ; Obsessive-Compulsive Disorder/physiopathology ; Polymorphism, Genetic/genetics* ; Promoter Regions, Genetic/genetics ; Proteomics/methods ; Serotonin Plasma Membrane Transport Proteins/genetics* ; Surveys and Questionnaires*
Keywords
Obsessive-compulsive disorder ; Serotonin transporter ; Polymorphism ; Component analysis
Abstract
Recently, on the basis of the effects of serotonin (5-HT) reuptake inhibitors in obsessive-compulsive disorder (OCD) treatment, several candidate genes related to 5-HT regulation have been hypothesized to play an important role in the development of OCD. One of them is 5-HT transporter gene. Therefore, the aims of this study were to investigate the associations between 5-HT transporter polymorphism and OCD. One hundred and twenty-four OCD patients and 171 normal controls participated in this study. Genomic DNA was extracted from their blood. Comparison of the genotypes and allele frequencies of the SERTPR polymorphism between the OCD group and the control group was made. Using principal component analysis, we derived four factors from thirteen main contents of the Y-BOCS checklist and investigated the association between these four factors and the SERTPR polymorphism. In this case-control study, we could not find any associations between the SERTPR polymorphism and the development of OCD. In the OCD group, patients with the L genotype had higher scores for the religious/somatic factor than with the S genotype. In conclusion, the SERTPR polymorphism does not affect the development of OCD. But SERTPR polymorphisms affect certain factors of OC symptoms. Moreover, the factor analytic approach used in the present study has identified meaningful symptom dimensions to help guide future research.
Full Text
http://www.karger.com/Article/FullText/88860
DOI
10.1159/000088860
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Chan Hyung(김찬형)
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151237
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