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Duodenal Somatostatinoma Associated with Diabetic Ketoacidosis Presumably Caused by Somatostatin-28 Hypersecretion

Authors
 Dol Mi Kim  ;  Chul Woo Ahn  ;  Kyung Rae Kim  ;  Soon Won Hong  ;  Moon Suk Nam  ;  Bong Soo Cha  ;  Sung Kil Lim  ;  Hyun Chul Lee  ;  Eun Jig Lee 
Citation
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.90(11) : 6310-6315, 2005 
Journal Title
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 
ISSN
 0021-972X 
Issue Date
2005
MeSH
Adult ; DNA/analysis ; Diabetic Ketoacidosis/complications* ; Duodenal Neoplasms/etiology* ; Duodenal Neoplasms/metabolism ; Duodenal Neoplasms/pathology ; Female ; Humans ; Immunohistochemistry ; Somatostatin/analysis ; Somatostatin/metabolism* ; Somatostatin-28 ; Somatostatinoma/etiology* ; Somatostatinoma/metabolism ; Somatostatinoma/pathology
Keywords
16105971
Abstract
CONTEXT: Extrapancreatic somatostatinoma is very rare and clinically distinguished from its pancreatic counterpart because somatostatinoma syndrome with mild diabetes is rare in extrapancreatic somatostatinoma because of poor secretion of somatostatin. Moreover, because somatostatin inhibits the secretion of insulin and glucagon simultaneously, true diabetic ketoacidosis (DKA) seldom ensues. PATIENT: A 23-yr-old woman presented with DKA and an abdominal mass. A computed tomography scan showed a huge, encapsulated mass in a duodenal submucous portion. A high circulating level of somatostatin was detected (67.2 pmol/liter; reference range, 0.6-7.3 pmol/liter). INTERVENTION: The tumor mass was successfully removed with Whipple's procedure, and the patient gradually recovered both clinically and biochemically. RESULTS: Immunohistochemical staining of the tumor tissue exhibited diffusely positive for somatostatin and somatostatin-28 but negative for insulin, glucagon, calcitonin, serotonin, and S-100. CONCLUSION: As far as we know, this is the first case report of gastrointestinal somatostatinoma associated with DKA.
Full Text
http://press.endocrine.org/doi/abs/10.1210/jc.2004-1904
DOI
10.1210/jc.2004-1904
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Dol Mi(김똘미)
Nam, Moon Suk(남문석)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151211
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