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Mortality risk factors of Acinetobacter baumannii bacteraemia

 J. Y. Choi  ;  Y. S. Park  ;  C. O. Kim  ;  Y. S. Park  ;  H. J. Yoon  ;  S. Y. Shin  ;  Y.-A. Kim  ;  Y. G. Song  ;  D. Yong  ;  K. Lee  ;  J. M. Kim 
 Internal Medicine Journal, Vol.35(10) : 599-603, 2005 
Journal Title
 Internal Medicine Journal 
Issue Date
BACKGROUND: Acinetobacter baumannii is one of the most important nosocomial pathogens, and its multiple antibiotic resistance has emerged as an obstacle in the treatment of these infections worldwide. AIMS: To identify risk factors of mortality for A. baumannii bacteraemia. METHODS: A retrospective cohort study of 72 patients with significant A. baumannii bacteraemia was conducted to evaluate risk factors for mortality. RESULTS: The median age of the 72 enrolled patients was 48 years, 96% of the cases were hospital-acquired, and the bacteraemia-related mortality rate was 29% (21 of 72 patients). Univariate analysis revealed that the risk factors for mortality included: an elevated acute physiology and chronic health evaluation (APACHE II) score, receipt of in vitro ineffective definitive antimicrobial therapy, in vitro A. baumannii resistance to cefoperazone/ sulbactam, neutropenia, and presentation with septic shock. Multivariate analysis reveals that the independent risk factors for mortality are neutropenia and elevated APACHE II scores. CONCLUSION: Risk factors such as neutropenia and elevated APACHE II scores are found to be associated with higher mortality rates of A. baumannii bacteraemia. Further study is necessary for the determination of optimal strategies for both the prevention and treatment of these infections.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
김연아(Kim, Yeon A)
김준명(Kim, June Myung)
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
박윤선(Park, Yoon Seon)
박윤수(Park, Yoon Soo)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
신소연(Shin, So Youn)
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
윤희정(Yoon, Hee Jung)
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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