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Expression of 15-lipoxygenase-1 in human nasal epithelium: Its implication in mucociliary differentiation

Authors
 Kyung-Su Kim  ;  Hee-Sun Chun  ;  Joo-Heon Yoon  ;  Jeung Gweon Lee  ;  Joo-Hwan Lee  ;  Jong-Bum Yoo 
Citation
 PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, Vol.73(2) : 77-83, 2005 
Journal Title
 PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 
ISSN
 0952-3278 
Issue Date
2005
Abstract
15-lipoxygenase-1 (15-LO-1) is involved in the differentiation of human tracheobronchial epithelial cells. Here, we investigated the relation between 15-LO-1 expression and the differentiation of human nasal epithelium. In retinoic acid (RA)-sufficient culture media, 15-LO-1 expression in normal human nasal epithelial cell time-dependently increased, but its expression was undetectable in RA-deficient culture media. Moreover, in RA-deficient culture media, IL-4 at 1 ng/ml concentration time-dependently induced 15-LO-1 expression. In addition, MUC8 gene expression, a marker of mucociliary differentiation, was up-regulated by 15-LO-1, which was itself induced by IL-4. In murine nasal mucosa, the expression of leukocyte type-12-LO, a functional equivalent of 15-LO-1, reduced after postnatal day 7. Our findings suggest that 15-LO-1 is related to the differentiation of human nasal epithelium, and that it may mediate the mucociliary differentiation of human nasal epithelium.
Full Text
http://www.sciencedirect.com/science/article/pii/S0952327805000992
DOI
10.1016/j.plefa.2005.05.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151186
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