Cited 11 times in
Expression of 15-lipoxygenase-1 in human nasal epithelium: Its implication in mucociliary differentiation
DC Field | Value | Language |
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dc.contributor.author | 김경수 | - |
dc.contributor.author | 윤주헌 | - |
dc.contributor.author | 이정권 | - |
dc.date.accessioned | 2017-10-26T06:41:35Z | - |
dc.date.available | 2017-10-26T06:41:35Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0952-3278 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151186 | - |
dc.description.abstract | 15-lipoxygenase-1 (15-LO-1) is involved in the differentiation of human tracheobronchial epithelial cells. Here, we investigated the relation between 15-LO-1 expression and the differentiation of human nasal epithelium. In retinoic acid (RA)-sufficient culture media, 15-LO-1 expression in normal human nasal epithelial cell time-dependently increased, but its expression was undetectable in RA-deficient culture media. Moreover, in RA-deficient culture media, IL-4 at 1 ng/ml concentration time-dependently induced 15-LO-1 expression. In addition, MUC8 gene expression, a marker of mucociliary differentiation, was up-regulated by 15-LO-1, which was itself induced by IL-4. In murine nasal mucosa, the expression of leukocyte type-12-LO, a functional equivalent of 15-LO-1, reduced after postnatal day 7. Our findings suggest that 15-LO-1 is related to the differentiation of human nasal epithelium, and that it may mediate the mucociliary differentiation of human nasal epithelium. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Churchill Livingstone | - |
dc.relation.isPartOf | PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression of 15-lipoxygenase-1 in human nasal epithelium: Its implication in mucociliary differentiation | - |
dc.type | Article | - |
dc.publisher.location | Scotland | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Kyung-Su Kim | - |
dc.contributor.googleauthor | Hee-Sun Chun | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Jeung Gweon Lee | - |
dc.contributor.googleauthor | Joo-Hwan Lee | - |
dc.contributor.googleauthor | Jong-Bum Yoo | - |
dc.identifier.doi | 10.1016/j.plefa.2005.05.023 | - |
dc.contributor.localId | A00298 | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A03095 | - |
dc.relation.journalcode | J02556 | - |
dc.identifier.eissn | 1532-2823 | - |
dc.identifier.pmid | 10.1016/j.plefa.2005.05.023 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0952327805000992 | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.alternativeName | Lee, Jeung Gweon | - |
dc.citation.volume | 73 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 77 | - |
dc.citation.endPage | 83 | - |
dc.identifier.bibliographicCitation | PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, Vol.73(2) : 77-83, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43518 | - |
dc.type.rims | ART | - |
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