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혈관 염증 지표들에 대한 온-라인 혈액여과투석법과 고유량 혈액투석법의 효과

Other Titles
 The Effects of On-Line Hemodiafiltration on Oxidative Stress and β2-Microglobulin in Comparison with High-Flux Hemodialysis 
Authors
 김현진  ;  김동기  ;  김형종  ;  류동열  ;  강신욱  ;  최규헌  ;  이호영  ;  한대석  ;  강이화  ;  신석균  ;  정은진  ;  박양숙 
Citation
 Korean Journal of Nephrology (대한신장학회지), Vol.24(2) : 255-264, 2005 
Journal Title
Korean Journal of Nephrology(대한신장학회지)
ISSN
 1225-0015 
Issue Date
2005
MeSH
Hemodiafiltration ; Malondialdehyde ; C-reactive protein ; Oxidative stress ; β2-Microglobulin
Keywords
Hemodiafiltration ; Malondialdehyde ; C-reactive protein ; Oxidative stress ; β2-Microglobulin
Abstract
Objective: On-line hemodiafiltration (OL-HDF) is a method that combines diffusive and convective solute transport component. OL-HDF provides improved solute clearance for both low-and large molecular-weight uremic toxins by enhancing convective clearance through highly permeable membranes. The aim of this study is to evaluate the effect of OL-HDF on oxidative stress and β2-microglobulin (β2-MG) in comparison with high-flux hemodialysis (HF-HD).
Methods: Twenty-one patients on thrice-weekly low-flux hemodialysis (LF-HD) for at least 6 months were studied. Every patient underwent OL-HDF and HF-HD for four weeks, respectively. There were 2 weeks of wash-out period in which patients were treated with LF-HD, between different treatment periods. Predialysis and postdialysis solute (creatinine, BUN, phosphate, β2-MG) concentrations were measured in the serum. In addition, predialysis solute (MDA, TAC, hsCRP) concentrations were measured.
Results: The urea reduction ratio (64.2±14.5 vs. 60.1±11.2%), Kt/V (1.4±0.2 vs. 1.3±0.3), β2-MG reduction ratio (53.8±9.7 vs. 44.3±8.7%) and β2-MG clearance (120.7±33.4 vs. 92.7±17.6 mL/min) were significantly higher in patients treated with on- line HDF compared with those treated with HF-HD. After 4 weeks of treatment, predialysis serum MDA levels were significantly lower in patients treated with OL-HDF compared with those treated with HF-HD (1.04±0.26 vs. 1.19±0.25 umol/L). After 4 weeks of treatment with 2 different dialysis modes, predialysis serum β2-MG (3.7±1.0 vs. 2.2±0.4 mg/ dL), MDA (1.19±0.21 vs. 1.04±0.26 umol/L), TAC (265.9±21.1 vs. 290.2±23.9 umol/L) and log hsCRP (0.07±0.51 vs. -0.23±0.62) levels were significantly improved compared to the baseline in OL-HDF patients. However, for HF-HD patients, only predialysis serum β2-MG level at 4 weeks was significantly lower than baseline (3.8±1.0 vs. 2.5±0.4 mg/dL).
Conclusion: This study shows that OL-HDF has been significant increase in oxidative stress and inflammatory marker removal compared to HF-HD.
Files in This Item:
T200500985.pdf Download
DOI
OAK-2005-05013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kang, Ea Wha(강이화)
Kim, Dong Ki(김동기)
Kim, Hyun Jin(김현진)
Kim, Hyung Jong(김형종)
Ryu, Dong Ryeol(류동열)
Lee, Ho Yung(이호영)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Dae Suk(한대석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151161
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