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Usefulness of Bone Metabolic Markers in the Diagnosis of Bone Metastasis from Lung Cancer

 Jae Ho Chung  ;  Moo Suk Park  ;  Young Sam Kim  ;  Joon Chang  ;  Joo Hang Kim  ;  Sung Kyu Kim  ;  Se Kyu Kim 
 YONSEI MEDICAL JOURNAL, Vol.46(3) : 388-393, 2005 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Alkaline Phosphatase/blood ; Amino Acids/urine ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/urine* ; Bone Neoplasms/blood ; Bone Neoplasms/secondary* ; Bone Neoplasms/urine ; Collagen/urine ; Collagen Type I ; Humans ; Lung Neoplasms/pathology* ; Middle Aged ; Peptides/urine ; Predictive Value of Tests
Lung neoplasms ; bone ; neoplasm metastasis ; deoxypyridinoline ; urinary N-telopeptide of type I collagen
Bone metastasis is common in lung cancer patient and the diagnosis of bone metastasis is usually made by using imaging techniques, especially bone scintigraphy. However, the diagnostic yield from bone scintigraphy is limited. The aim of this study is to assess the clinical usefulness of urinary pyridinoline cross-linked N-telopeptides of Type I collagen (NTx), urinary deoxypyridinoline (DPD), and serum alkaline phosphatase (ALP) in the assessment of bone metastasis in patients with lung cancer. Urinary NTx, DPD, and serum ALP were measured in 151 lung cancer patients (33 with and 118 without bone metastasis). Lung cancer patients with bone metastasis had a higher urinary excretion of NTx and DPD, and a higher serum ALP than those without bone metastasis. NTx had a better receiver operating characteristic (ROC) curve than DPD and ALP, since the areas under the ROC curve were 0.82, 0.79, and 0.71, respectively. Although correlation coefficients among NTx, DPD and ALP were significantly positive (p < 0.005), the strongest relationship was appeared between NTx and DPD (R=0.616). In conclusion, our results showed the utility of the new bone markers in detecting bone metastasis and suggested that measurement of urinary NTx was valid diagnostic method of bone metastasis from lung cancer.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Kyu(김성규)
Kim, Se Kyu(김세규)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Joo Hang(김주항)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
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