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Usefulness of Bone Metabolic Markers in the Diagnosis of Bone Metastasis from Lung Cancer

DC Field Value Language
dc.contributor.author김성규-
dc.contributor.author김세규-
dc.contributor.author김영삼-
dc.contributor.author김주항-
dc.contributor.author박무석-
dc.contributor.author장준-
dc.date.accessioned2017-10-26T06:38:35Z-
dc.date.available2017-10-26T06:38:35Z-
dc.date.issued2005-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151118-
dc.description.abstractBone metastasis is common in lung cancer patient and the diagnosis of bone metastasis is usually made by using imaging techniques, especially bone scintigraphy. However, the diagnostic yield from bone scintigraphy is limited. The aim of this study is to assess the clinical usefulness of urinary pyridinoline cross-linked N-telopeptides of Type I collagen (NTx), urinary deoxypyridinoline (DPD), and serum alkaline phosphatase (ALP) in the assessment of bone metastasis in patients with lung cancer. Urinary NTx, DPD, and serum ALP were measured in 151 lung cancer patients (33 with and 118 without bone metastasis). Lung cancer patients with bone metastasis had a higher urinary excretion of NTx and DPD, and a higher serum ALP than those without bone metastasis. NTx had a better receiver operating characteristic (ROC) curve than DPD and ALP, since the areas under the ROC curve were 0.82, 0.79, and 0.71, respectively. Although correlation coefficients among NTx, DPD and ALP were significantly positive (p < 0.005), the strongest relationship was appeared between NTx and DPD (R=0.616). In conclusion, our results showed the utility of the new bone markers in detecting bone metastasis and suggested that measurement of urinary NTx was valid diagnostic method of bone metastasis from lung cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlkaline Phosphatase/blood-
dc.subject.MESHAmino Acids/urine-
dc.subject.MESHBiomarkers, Tumor/blood-
dc.subject.MESHBiomarkers, Tumor/urine*-
dc.subject.MESHBone Neoplasms/blood-
dc.subject.MESHBone Neoplasms/secondary*-
dc.subject.MESHBone Neoplasms/urine-
dc.subject.MESHCollagen/urine-
dc.subject.MESHCollagen Type I-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/pathology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeptides/urine-
dc.subject.MESHPredictive Value of Tests-
dc.titleUsefulness of Bone Metabolic Markers in the Diagnosis of Bone Metastasis from Lung Cancer-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJae Ho Chung-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorSung Kyu Kim-
dc.contributor.googleauthorSe Kyu Kim-
dc.identifier.doi10.3349/ymj.2005.46.3.388-
dc.contributor.localIdA00564-
dc.contributor.localIdA00602-
dc.contributor.localIdA00707-
dc.contributor.localIdA00945-
dc.contributor.localIdA01457-
dc.contributor.localIdA03472-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid15988811-
dc.subject.keywordLung neoplasms-
dc.subject.keywordbone-
dc.subject.keywordneoplasm metastasis-
dc.subject.keyworddeoxypyridinoline-
dc.subject.keywordurinary N-telopeptide of type I collagen-
dc.contributor.alternativeNameKim, Sung Kyu-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameChang, Joon-
dc.citation.volume46-
dc.citation.number3-
dc.citation.startPage388-
dc.citation.endPage393-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.46(3) : 388-393, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid43460-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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