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Pretreatment anemia is associated with poorer survival in patients with stage I and II gastric cancer

Authors
 Jian Guo Shen  ;  Jae Ho Cheong  ;  Woo Jin Hyung  ;  Junuk Kim  ;  Seung Ho Choi  ;  Sung Hoon Noh 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.91(2) : 126-130, 2005 
Journal Title
JOURNAL OF SURGICAL ONCOLOGY
ISSN
 0022-4790 
Issue Date
2005
MeSH
Adult ; Aged ; Aged, 80 and over ; Anemia/complications ; Anemia/therapy* ; Blood Transfusion ; Cohort Studies ; Female ; Gastrectomy*/mortality ; Humans ; Lymph Node Excision ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Nutritional Status ; Prognosis ; Retrospective Studies ; Splenectomy ; Stomach Neoplasms/complications ; Stomach Neoplasms/mortality* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Survival Rate
Keywords
anemia ; gastric cancer ; prognosis ; survival
Abstract
BACKGROUND AND OBJECTIVES: A negative correlation between anemia and outcome has been demonstrated in various cancers treated with radiotherapy. However, it is rarely studied whether this correlation may exist in surgical setting. Our aim was to investigate the relationship between pretreatment anemia and survival in surgically treated patients with gastric cancer. METHODS: A total of 1,688 patients who had undergone curative resection for gastric cancer between 1991 and 1995 were reviewed. Anemia was defined as a hemoglobin level <12.0 g/dl. The influence of anemia on patient overall survival was evaluated by univariate and multivariate analysis. RESULTS: Pretreatment anemia was present in 39.9% of the patients. The 10-year overall survival rate in anemic patients was 48.2% as compared with 62.6% in nonanemic patients (P < 0.001). In subgroup analysis according to the stage, the significant difference in 10-year overall survival rate between anemic and nonanemic patients was found in stage I and II gastric cancer (76.1% vs. 83.5% in stage I, P = 0.030; 55.1% vs. 67.2% in stage II, P = 0.043). On multivariate analysis, anemia was an independent prognostic predictor in patients with stage I and II disease (P = 0.007; RR, 1.466; 95% CI, 1.109-1.937). CONCLUSIONS: Pretreatment anemia was found to have an independent relationship to the long-term survival of patients with stage I and II gastric cancer.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.20272/abstract
DOI
10.1002/jso.20272
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151049
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