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생후 첫 1주간 기계적 환기요법을 받는 극소 저출생 체중아에서 기관지 폐이형성증 발생의 조기 예측

Other Titles
 Early Prediction of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants with Mechanical Ventilation in the First Week of Life 
Authors
 최은나  ;  박민수  ;  박국인  ;  남궁란  ;  이철  ;  구회경 
Citation
 Journal of the Korean Society of Neonatology (대한신생아학회지), Vol.12(2) : 150-157, 2005 
Journal Title
 Journal of the Korean Society of Neonatology (대한신생아학회지) 
ISSN
 1226-1513 
Issue Date
2005
MeSH
Bronchopulmonary dysplasia ; Very low birth weight infant ; Risk factors
Keywords
Bronchopulmonary dysplasia ; Very low birth weight infant ; Risk factors
Abstract
Purpose: Multifactorial in pathogenesis, bronchopulmonary dysplasia is difficult to predict based on any single factor, especially early in life. We evaluated clinical and ventilatory parameters in the first week of life, and their combinations were tested for early prediction of BPD. Methods: Eighty-one very low birth weight (VLBW) infants born at gestational ages <32 weeks and mechanically ventilated for at least first 7 days were selected and classified into BPD (n=48, radiological findings and oxygen dependency at postconceptional age of 36 weeks) and non-BPD (n=33) groups. Clinical and ventilatory parameters on days 1, 4 and 7 were analyzed. Chi-square and t-test were used to compare individual variables between two groups. Multiple logistic regression analysis was done to identify risk factors for BPD. Results: The mean gestational age and birth weight were lower in BPD group. In multivariate analysis, significant risk factors that predict BPD were gestational age<30 weeks (OR 0.112, 95% CI 0.016-0.767), maximum MAP ≥4.5 on day 7 (OR 3.982, 95% CI 1.046-15.162) and maximum FiO2≥0.3 on day 7 (OR 7.626, 95% CI 1.570-37.054). The combination of these factors for prediction of BPD had a 79% positive predictive value with an 85% sensitivity. Conclusion: A number of clinical and ventilatory parameters in combination (gestation, maximum MAP and FiO2 on day 7) can predict BPD in VLBW infants early in life with a relatively high sensitivity and positive predictiveness. With early identification of infants prone to BPD, the clinicians may resort to more active measures to minimize lung injury and to prevent BPD.
Files in This Item:
T200500766.pdf Download
DOI
OAK-2005-04316
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Koo, Hoe Kyoung(구회경)
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Lee, Chul(이철)
Choi, Eun Na(최은나)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151015
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