한국형 양극성 장애 약물치료 알고리듬의 적용 가능성(Ⅱ)：약물의 선택

Abstract

Objective：The Korean College of Neuropsychopharmacology and the Korean Academy of Schizophrenia developed the Korean algorithm project for bipolar disorder to aid clinical decisions. The purpose of this study was to investigate the prescribing tendency of psychopharmacological agents such as mood stabilizers and antipsychotics according to the Korean Medication Algorithm for Bipolar Disorder (KMAP-BP) in clinical settings. Methods： Ninety-two patients were treated according to the algorithm. Among them the selection and dose of drugs were investigated in 71 patients whose precise medication records were available. Results：Lithium (n=37) and divalproex (n=33) were used as mood stabilizers and combination treatment with both medications was done for one patient. Carbamazepine was not used. During the maintenance period, dosage of mood stabilizer was higher for mixed and psychotic mania compared with euphoric mania. Antipsychotic drug was co-administrated with a mood stabilizer from the beginning of the treatment in 62 of 71 patients and risperidone (69.4%) was the most preferred drug. Of those 62 patients who were treated with antipsychotics, 24 patients were initially taking anti-parkinsonian agents. Conclusion：This study investigated the prescribing tendency of clinicians who practiced according to the KMAP-BP. Considering the results of this study, further research is needed to revise KMAP-BP.