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Treponema lecithinolyticum lipopolysaccharide에 의한 matrix metalloproteinase-9의 발현

Other Titles
 Effect of Treponema lecithinolyticum lipopolysaccharide on matrix metalloproteinase-9 expression 
 남정아  ;  문선영  ;  이진욱  ;  차정헌  ;  최봉규  ;  유윤정 
 Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.35(3) : 675-686, 2005 
Journal Title
Journal of Korean Academy of Periodontology(대한치주과학회지)
Issue Date
Treponema lecithinolyticum ; lipopolysaccharide ; MMP-9
Treponema lecithinolyticum ; lipopolysaccharide ; MMP-9
Bone resorption involves sequential stages of osteoclast precursor migration and differen-tiation of osteoclast precursors into multinucleated osteoclasts. Stromal cell derived factor (SDF)-1 is a chemotactic factor for osteoclast precursor migration. Matrix metalloproteinase (MMP)-9 is involved in migration of osteoclast precursors and activation of interleukin(IL)-1beta. Alveolar bone destruction is a characteristic feature of periodontal disease. Treponema lecithinolyticum is a oral spirochete isolated from the periodontal lesions. The effect of lipopolysaccharide(LPS) from T. lecithinolyticum on expression of SDF-1 and MMP-9 was examined in cocultures of bone marrow cells and osteblasts derived from mouse calvariae. T. lecithinolyticum LPS increased expression of MMP-9 in the coculture. Polymyxin B, an inhibitor of LPS, abolished the increase of MMP-9 mRNA expression by LPS. LPS did not increase the expression of SDF-1, IL-1beta and tumor necrosis factor(TNF)-alpha mRNA in cocultures. Prostaglandin E2(PGE2) up-regulated the expression of MMP-9 and NS398, an inhibitor of PGE2 synthesis, down-regulated the induction of MMP-9 expression by T. lecithinolyticm LPS. These results suggest that T. lecithinolytium LPS increases MMP-9 expression in bone cells via PGE2 and that the induction of MMP-9 expression by T. lecithinolyticum LPS is involved in alveolar bone destruction of periodontitis patients by the increase of osteoclast precursor migration and the activation of bone resorption-inducing cytokine.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Nam, Jeong Ah(남정아)
Moon, Sun Young(문선영)
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Cha, Jeong Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
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