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Barbed micro-spikes for micro-scale biopsy

Authors
 Sangwon Byun  ;  Jung-Min Lim  ;  Seung-Joon Paik  ;  Ahra Lee  ;  Kyo-in Koo  ;  Sunkil Park  ;  Jaehong Park  ;  Byoung-Doo Choi  ;  Jong Mo Seo  ;  Kyung-ah Kim  ;  Hum Chung  ;  Si Young Song  ;  Doyoung Jeon  ;  Dongil Cho 
Citation
 JOURNAL OF MICROMECHANICS AND MICROENGINEERING, Vol.15(6) : 1279-1284, 2005 
Journal Title
 JOURNAL OF MICROMECHANICS AND MICROENGINEERING 
ISSN
 0960-1317 
Issue Date
2005
Abstract
Single-crystal silicon planar micro-spikes with protruding barbs are developed for micro-scale biopsy and the feasibility of using the micro-spike as a micro-scale biopsy tool is evaluated for the first time. The fabrication process utilizes a deep silicon etch to define the micro-spike outline, resulting in protruding barbs of various shapes. Shanks of the fabricated micro-spikes are 3 mm long, 100 µm thick and 250 µm wide. Barbs protruding from micro-spike shanks facilitate the biopsy procedure by tearing off and retaining samples from target tissues. Micro-spikes with barbs successfully extracted tissue samples from the small intestines of the anesthetized pig, whereas micro-spikes without barbs failed to obtain a biopsy sample. Parylene coating can be applied to improve the biocompatibility of the micro-spike without deteriorating the biopsy function of the micro-spike. In addition, to show that the biopsy with the micro-spike can be applied to tissue analysis, samples obtained by micro-spikes were examined using immunofluorescent staining. Nuclei and F-actin of cells which are extracted by the micro-spike from a transwell were clearly visualized by immunofluorescent staining.
Full Text
http://iopscience.iop.org/0960-1317/15/6/020
DOI
10.1088/0960-1317/15/6/020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150923
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