Cited 36 times in
Barbed micro-spikes for micro-scale biopsy
DC Field | Value | Language |
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dc.contributor.author | 송시영 | - |
dc.date.accessioned | 2017-10-26T06:31:18Z | - |
dc.date.available | 2017-10-26T06:31:18Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0960-1317 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150923 | - |
dc.description.abstract | Single-crystal silicon planar micro-spikes with protruding barbs are developed for micro-scale biopsy and the feasibility of using the micro-spike as a micro-scale biopsy tool is evaluated for the first time. The fabrication process utilizes a deep silicon etch to define the micro-spike outline, resulting in protruding barbs of various shapes. Shanks of the fabricated micro-spikes are 3 mm long, 100 µm thick and 250 µm wide. Barbs protruding from micro-spike shanks facilitate the biopsy procedure by tearing off and retaining samples from target tissues. Micro-spikes with barbs successfully extracted tissue samples from the small intestines of the anesthetized pig, whereas micro-spikes without barbs failed to obtain a biopsy sample. Parylene coating can be applied to improve the biocompatibility of the micro-spike without deteriorating the biopsy function of the micro-spike. In addition, to show that the biopsy with the micro-spike can be applied to tissue analysis, samples obtained by micro-spikes were examined using immunofluorescent staining. Nuclei and F-actin of cells which are extracted by the micro-spike from a transwell were clearly visualized by immunofluorescent staining. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOP | - |
dc.relation.isPartOf | JOURNAL OF MICROMECHANICS AND MICROENGINEERING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Barbed micro-spikes for micro-scale biopsy | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sangwon Byun | - |
dc.contributor.googleauthor | Jung-Min Lim | - |
dc.contributor.googleauthor | Seung-Joon Paik | - |
dc.contributor.googleauthor | Ahra Lee | - |
dc.contributor.googleauthor | Kyo-in Koo | - |
dc.contributor.googleauthor | Sunkil Park | - |
dc.contributor.googleauthor | Jaehong Park | - |
dc.contributor.googleauthor | Byoung-Doo Choi | - |
dc.contributor.googleauthor | Jong Mo Seo | - |
dc.contributor.googleauthor | Kyung-ah Kim | - |
dc.contributor.googleauthor | Hum Chung | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Doyoung Jeon | - |
dc.contributor.googleauthor | Dongil Cho | - |
dc.identifier.doi | 10.1088/0960-1317/15/6/020 | - |
dc.contributor.localId | A02035 | - |
dc.relation.journalcode | J01598 | - |
dc.identifier.eissn | 1361-6439 | - |
dc.identifier.pmid | 10.1088/0960-1317/15/6/020 | - |
dc.identifier.url | http://iopscience.iop.org/0960-1317/15/6/020 | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1279 | - |
dc.citation.endPage | 1284 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROMECHANICS AND MICROENGINEERING, Vol.15(6) : 1279-1284, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42774 | - |
dc.type.rims | ART | - |
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