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Barbed micro-spikes for micro-scale biopsy

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dc.contributor.author송시영-
dc.date.accessioned2017-10-26T06:31:18Z-
dc.date.available2017-10-26T06:31:18Z-
dc.date.issued2005-
dc.identifier.issn0960-1317-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150923-
dc.description.abstractSingle-crystal silicon planar micro-spikes with protruding barbs are developed for micro-scale biopsy and the feasibility of using the micro-spike as a micro-scale biopsy tool is evaluated for the first time. The fabrication process utilizes a deep silicon etch to define the micro-spike outline, resulting in protruding barbs of various shapes. Shanks of the fabricated micro-spikes are 3 mm long, 100 µm thick and 250 µm wide. Barbs protruding from micro-spike shanks facilitate the biopsy procedure by tearing off and retaining samples from target tissues. Micro-spikes with barbs successfully extracted tissue samples from the small intestines of the anesthetized pig, whereas micro-spikes without barbs failed to obtain a biopsy sample. Parylene coating can be applied to improve the biocompatibility of the micro-spike without deteriorating the biopsy function of the micro-spike. In addition, to show that the biopsy with the micro-spike can be applied to tissue analysis, samples obtained by micro-spikes were examined using immunofluorescent staining. Nuclei and F-actin of cells which are extracted by the micro-spike from a transwell were clearly visualized by immunofluorescent staining.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOP-
dc.relation.isPartOfJOURNAL OF MICROMECHANICS AND MICROENGINEERING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBarbed micro-spikes for micro-scale biopsy-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSangwon Byun-
dc.contributor.googleauthorJung-Min Lim-
dc.contributor.googleauthorSeung-Joon Paik-
dc.contributor.googleauthorAhra Lee-
dc.contributor.googleauthorKyo-in Koo-
dc.contributor.googleauthorSunkil Park-
dc.contributor.googleauthorJaehong Park-
dc.contributor.googleauthorByoung-Doo Choi-
dc.contributor.googleauthorJong Mo Seo-
dc.contributor.googleauthorKyung-ah Kim-
dc.contributor.googleauthorHum Chung-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorDoyoung Jeon-
dc.contributor.googleauthorDongil Cho-
dc.identifier.doi10.1088/0960-1317/15/6/020-
dc.contributor.localIdA02035-
dc.relation.journalcodeJ01598-
dc.identifier.eissn1361-6439-
dc.identifier.pmid10.1088/0960-1317/15/6/020-
dc.identifier.urlhttp://iopscience.iop.org/0960-1317/15/6/020-
dc.contributor.alternativeNameSong, Si Young-
dc.citation.volume15-
dc.citation.number6-
dc.citation.startPage1279-
dc.citation.endPage1284-
dc.identifier.bibliographicCitationJOURNAL OF MICROMECHANICS AND MICROENGINEERING, Vol.15(6) : 1279-1284, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid42774-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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