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Serotonin Transporter Gene Polymorphism and Personality Traits in a Korean Population

Authors
 Kim S.J.  ;  Kim Y.S.  ;  Choi N.K.  ;  Hong H.J.  ;  Lee H.S.  ;  Kim C.-H. 
Citation
 NEUROPSYCHOBIOLOGY, Vol.51(4) : 243-247, 2005 
Journal Title
NEUROPSYCHOBIOLOGY
ISSN
 0302-282X 
Issue Date
2005
MeSH
Adult ; DNA/analysis ; Female ; Genotype ; Humans ; Korea/ethnology ; Male ; Membrane Glycoproteins/genetics* ; Membrane Transport Proteins/genetics* ; Nerve Tissue Proteins/genetics* ; Personality/genetics* ; Personality Inventory ; Polymorphism, Genetic* ; Promoter Regions, Genetic/genetics ; Psychometrics/methods ; RNA, Messenger/biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Serotonin Plasma Membrane Transport Proteins ; Sex Factors ; Temperament/physiology
Keywords
15905629
Abstract
Recently, there has been growing enthusiasm for exploring biological approaches to personality, especially in the area of genetic research into the identification of those genes responsible for particular personality traits. The aim of this study was to investigate the association between the serotonin transporter-linked promoter region (5-HTTLPR) polymorphism and personality traits. We recruited 211 unrelated, normal subjects. The Korean version of the Temperament and Character Inventory (TCI) was used to assess certain personality traits. From blood samples taken from the subjects, DNA was isolated using standard techniques and the 5-HTTLPR polymorphism was genotyped by means of polymerase chain reaction and electrophoresis. We classified the subject into the s/s, s/l, and l/l groups according to their genotype. The differences in the temperament factors of the TCI between group S (s/s genotype) and group L (s/l + l/l genotype) were assessed, after the inclusion of gender and age as covariates in the analysis of variance. After controlling for gender and age, there were no associations between the harm avoidance, novelty seeking, and reward dependence scores and the genotypes. However, the persistence score of group S was significantly higher than that of group L. Our results suggest that the 5-HTTLPR polymorphism may be associated with the persistence score of the TCI in a normal Korean population.
Full Text
http://www.karger.com/Article/FullText/85819
DOI
10.1159/000085819
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Chan Hyung(김찬형)
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150915
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