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Promoter -202 A/C Polymorphism of Insulin-Like Growth Factor Binding Protein-3 Gene and Non-small Cell Lung Cancer Risk

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dc.contributor.author강신명-
dc.contributor.author김성규-
dc.contributor.author김세규-
dc.contributor.author김영삼-
dc.contributor.author문진욱-
dc.contributor.author박무석-
dc.contributor.author박재준-
dc.contributor.author변민광-
dc.contributor.author신주혜-
dc.contributor.author유경남-
dc.contributor.author장양수-
dc.contributor.author장준-
dc.contributor.author정우영-
dc.contributor.author한창훈-
dc.contributor.author장윤수-
dc.date.accessioned2017-10-26T06:22:29Z-
dc.date.available2017-10-26T06:22:29Z-
dc.date.issued2005-
dc.identifier.issn1738-3536-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150846-
dc.description.abstract인슐린양 성장 인자 결합 단백-3(Insulin-like growth factor (IGF) binding protein-3 (IGFBP- 는 혈액 내에서 와 3)) IGF 결합하여 복합체 혹은 저장소로 작용함으로써 가 수용체에 결합하는 것을 방해하여 의 항세포사멸 , IGF IGF (anti-및 세포분열 촉진의 기능을 억제한다 하지만 특정 상황에서는 도리어 apoptosis) . , IGFBP- 가 의 파괴를 억제하여 3 IGF 에 의한 암세포의 분화 및 성장을 촉진할 수도 있다는 것이 알려져 있다 대부분의 환자에서 혈액내 IGF . IGFBP- 수치는 3IGFBP- 유전자의 3 - 좌위 의 다형성 에 의해 크게 영향을 받는다 따라서 저자 등은 제한 효소 202 (locus) (polymorphism) 를 이용하여 비소세포폐암 환자의 (restriction enzyme) IGFBP- 유전자 3 - 좌위의 다형성을 분석함으로써 이 좌위의 202 ,다형성이 비소세포폐암의 위험도와 연관되어 있는지 조사하였다 본 연구는 명의 비소세포폐암 환자군과 연령 성별 . 104 흡연력이 비슷한 명의 대조군을 비교 분석하였다 대조군에서 104 . - 좌위 유전자 다형성의 빈도는 202 AA형 명 48 (46.2%),AC형 명 45 (43.3%), CC형 명 이었고 비소세포폐암 환자군에서 11 (10.5%) , - 좌위 유전자 다형성의 빈도는 202 AA형 명 67(64.4%), AC형 명 35 (33.7%), CC형 명 이었다 2 (1.9%) . - 좌위의 유전자 다형성에 있어서 대조군과 비소세포폐암 환자 202 군 사이에 유의한 빈도 차이가 있었으며 ( p< 0.05, Pearson’s χ2 비소세포폐암의 위험도는 test), – -좌위의 202 AA형에서 가장 높고 CC형에서 가장 낮았다. CC형을 기준으로 하면 AC형의 비교 위험도는 신뢰구간 2.60 (95% : 0.89 - 이었으 8.60) 며 AA형의 비교 위험도는 신뢰구간 5.89 (95% : 1.92 - 이었다 본 연구 결과는 21.16) . , IGFBP- 유전자의 3 - 좌위 202 (locus) 의 다형성 이 비소세포폐암의 위험인자 중의 하나일 가능성을 제시하며 따라서 비소세포폐암에 대한 항암 (polymorphism) , 치료 개발에 있어서 새로운 표적이 될 가능성을 시사한다.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher대한결핵 및 호흡기학회-
dc.relation.isPartOfTUBERCULOSIS AND RESPIRATORY DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHInsulin-like growth factor (IGF)-
dc.subject.MESHInsulin-like growth factor binding protein-3 (IGFBP-3)-
dc.subject.MESHNon-small cell lung cancer (NSCLC)-
dc.subject.MESHPromoter -202 A/C polymorphism-
dc.subject.MESHRestriction fragment length polymorphism(RFLP)-
dc.titlePromoter -202 A/C Polymorphism of Insulin-Like Growth Factor Binding Protein-3 Gene and Non-small Cell Lung Cancer Risk-
dc.title.alternative인슐린양 성장 인자 결합 단백-3 유전자-202 좌위의 다형성에 따른 비소세포폐암의 위험도-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor문진욱-
dc.contributor.googleauthor장윤수-
dc.contributor.googleauthor한창훈-
dc.contributor.googleauthor강신명-
dc.contributor.googleauthor박무석-
dc.contributor.googleauthor변민광-
dc.contributor.googleauthor정우영-
dc.contributor.googleauthor박재준-
dc.contributor.googleauthor유경남-
dc.contributor.googleauthor신주혜-
dc.contributor.googleauthor김영삼-
dc.identifier.doiOAK-2005-04894-
dc.contributor.localIdA00051-
dc.contributor.localIdA00564-
dc.contributor.localIdA00602-
dc.contributor.localIdA00707-
dc.contributor.localIdA01387-
dc.contributor.localIdA01457-
dc.contributor.localIdA01636-
dc.contributor.localIdA01848-
dc.contributor.localIdA02155-
dc.contributor.localIdA02452-
dc.contributor.localIdA03448-
dc.contributor.localIdA03472-
dc.contributor.localIdA03667-
dc.contributor.localIdA04331-
dc.relation.journalcodeJ02761-
dc.identifier.eissn2005-6184-
dc.relation.journalsince2004~-
dc.relation.journalbefore~2004 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환)-
dc.subject.keywordInsulin-like growth factor (IGF)-
dc.subject.keywordInsulin-like growth factor binding protein-3 (IGFBP-3)-
dc.subject.keywordNon-small cell lung cancer (NSCLC)-
dc.subject.keywordPromoter -202 A/C polymorphism-
dc.subject.keywordRestriction fragment length polymorphism(RFLP)-
dc.contributor.alternativeNameKang, Shin Myung-
dc.contributor.alternativeNameKim, Sung Kyu-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameMoon, Jin Wook-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameByun, Min Kwang-
dc.contributor.alternativeNameShin, Ju Hye-
dc.contributor.alternativeNameYoo, Kyeong Nam-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Woo Young-
dc.contributor.alternativeNameHahn, Chang Hoon-
dc.citation.volume58-
dc.citation.number4-
dc.citation.startPage359-
dc.citation.endPage366-
dc.identifier.bibliographicCitationTUBERCULOSIS AND RESPIRATORY DISEASES, Vol.58(4) : 359-366, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid44764-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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