Cited 49 times in
Evaluation of the extraction method for the cytotoxicity testing of latex gloves
DC Field | Value | Language |
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dc.contributor.author | 권오헌 | - |
dc.contributor.author | 나동균 | - |
dc.contributor.author | 박종철 | - |
dc.contributor.author | 백현숙 | - |
dc.contributor.author | 한동욱 | - |
dc.date.accessioned | 2017-10-26T06:19:03Z | - |
dc.date.available | 2017-10-26T06:19:03Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150785 | - |
dc.description.abstract | In this study, the cytotoxicity of medical latex gloves to cultured L-929 cells was determined using various extraction conditions. According to the extraction time and temperature, three types of extraction conditions were used: 1) 24 h at 37℃; 2) 72 h at 37℃; 3) 72 h at 50℃. Also, four different extraction vehicles were used, namely, distilled water (DW), 9 g/l sodium chloride (saline) in DW, and culture media with or without serum. Under the above-mentioned conditions, the samples were extracted and then 2-fold serially diluted in the concentration range 3.13 - 50%. When extracted with either DW or saline for 24 h or 72 h at 37℃, only 50% diluted samples showed distinct cytotoxicity to L-929 cells. Moreover, no cytotoxic potentials were observed when gloves were extracted with DW or saline at 50℃ for 72 h. Cytotoxicity was markedly greater when gloves were extracted with culture medium, irrespective of the presence of serum in the medium. These results suggest that optimal extraction conditions should be established for the cytotoxicity evaluations of biomaterials and medical devices. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Survival/drug effects* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Culture Media | - |
dc.subject.MESH | Gloves, Protective | - |
dc.subject.MESH | Latex/isolation & purification* | - |
dc.subject.MESH | Latex/toxicity* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Temperature | - |
dc.subject.MESH | Toxicity Tests/methods* | - |
dc.title | Evaluation of the extraction method for the cytotoxicity testing of latex gloves | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | Others | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.department | Dept. of Plastic and Reconstructive Surgery (성형외과학교실) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.department | Severance Hospital (세브란스병원) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Hyun Sook Baek | - |
dc.contributor.googleauthor | Ja Young Yoo | - |
dc.contributor.googleauthor | Dong Kyun Rah | - |
dc.contributor.googleauthor | Dong-Wook Han | - |
dc.contributor.googleauthor | Dong Hee Lee | - |
dc.contributor.googleauthor | Oh-Hun Kwon | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.identifier.doi | 10.3349/ymj.2005.46.4.579 | - |
dc.contributor.localId | A00237 | - |
dc.contributor.localId | A01229 | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A01843 | - |
dc.contributor.localId | A04275 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 16127787 | - |
dc.subject.keyword | Extraction conditions | - |
dc.subject.keyword | cytotoxicity | - |
dc.subject.keyword | latex gloves | - |
dc.subject.keyword | L-929 cells | - |
dc.subject.keyword | medical devices | - |
dc.contributor.alternativeName | Kwon, Oh Hun | - |
dc.contributor.alternativeName | Rah, Dong Kyun | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Baek, Hyun Sook | - |
dc.contributor.alternativeName | Han, Dong Wook | - |
dc.citation.volume | 46 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 579 | - |
dc.citation.endPage | 583 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.46(4) : 579-583, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 44750 | - |
dc.type.rims | ART | - |
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